Tadacip

Tadacip is a medication used to treat erectile dysfunction and benign prostate hyperplasia. It contains the active ingredient tadalafil.

There are certain things you need to know before you use Tadacip. This includes what it is, its effects, and how it can help. We’ll talk about all these things in this article and include a few natural alternatives you can try first.

What is Tadacip?

Tadacip is a generic form of the medication called tadalafil. It is the product of Cipla, a multinational pharmaceutical company based in Mumbai, India.

Tadacip is a phosphodiesterase 5 (PDE5) inhibitor used to induce and maintain an erection for sexual intercourse in erectile dysfunction (ED) patients. It means it can stop the actions of PDE5 in the penis and increase blood flow into it long enough for it to become erect. This same ability and base ingredient are present in another famous and more expensive ED treatment drug, Cialis. Tadacip is also used to treat benign prostatic hyperplasia (BPH).

Tadacip is a long-acting drug, with its long duration of action being a plus point compared to other drugs of this kind.

Dosage of Tadacip

Tadacip comes in two doses:

10 mg
20 mg

It comes as a small, yellow-colored, almond-shaped tablet. It is in packs of four or ten tablets in one strip.

If you suffer from ED, your doctor will first assess you for your condition and any underlying diseases you may have before prescribing it.

The beginning dosage is 10 mg. Your doctor may increase or decrease your dose depending on how well you respond to the drug. You should take Tadacip only when you are about to have sex. There is no need to take it daily unless it is indicated. The maximum dose for it is one tablet once a day. Any more and it may cause some unwanted effects.

If you have BPH, your dosage will depend on what your doctor prescribes you. In this case, you’ll have to take your medications at the right time daily.

How Long Does it Take for Tadacip to Work?

It takes about 30 to 60 minutes for Tadacip to start working. In some men, it could take slightly longer. Tadacip needs to be taken about 30 minutes before having sex. Sexual stimulation is also essential for it to work. Tadacip is not an aphrodisiac and will not increase libido.

How Long Can Tadacip Last?

Tadacip has an ideal advantage over most other medications of its kind. It lasts for a long time, almost up to 36 hours, and has a half-life of nearly 17.5 hours. Most other ED medications like Viagra last for only about 3 hours. Tadacip may help you be more sexually active for much longer.

What is the Cost of Tadacip?

Tadacip is about $ 1.55 per 20 mg tablet. This is less compared to other brands. However, Tadacip is a prescription-only drug in most countries.

The History of Tadacip

Tadalafil, the active ingredient of Tadacip, began as a potential heart and high blood pressure medication back in 1993. The researchers found out that this drug could induce erections in patients with ED. After being patented in 1994, this drug was produced with the name Cialis by the company ICOS.

In 2003, the FDA approved the use of this drug in ED treatment. Lilly ICOS then began producing tadalafil exclusively. However, its patent ended in 2017, following which many companies started manufacturing it at a much lower price. Cipla was one of them, and began producing its version of tadalafil and named it Tadacip. Today, Tadacip is sold to most countries in the world.

Metabolization of Tadacip

Tadacip is metabolized in the liver and is handled by the CYP3A4 enzyme. Therefore, other drugs can react with this enzyme and can either shorten or lengthen the amount and abilities of Tadacip in the body.

Mechanism of Action of Tadacip

Phosphodiesterases are enzymes that are present in different parts of the body. Phosphodiesterase-5 is present in vascular smooth muscles, platelets,corpora cavernosa, and the penis. Tadalafil, the base ingredient of Tadacip, is a cGMP-specific phosphodiesterase 5 (PDE5) inhibitor.

Usually, nerves in the pelvis are stimulated during sexual excitement. Following this, nitric oxide (NO) gets released. NO induces the release of cyclic guanosine monophosphate (cGMP). The cGMP causes an increased amount of blood flow into the penis. This happens due to the dilation of the arteries in the penis and the smooth muscles of corpora cavernosa. And thus, an erection occurs.

When PDE5 stops the actions of NO, no erection can occur.

Tadacip inhibits the PDE-5 and relaxes the blood vessels and smooth muscles in the penis. As a result, it increases their blood flow and helps maintain an erection. However, it needs sexual stimulation to do its work.

Uses for Tadacip

Tadacip is for those who can’t get an erectionor maintain it long enough to have sex. This condition is called erectile dysfunction and affects about a third of all men.

It is also used to treat benign prostatic hyperplasia and, lately, pulmonary hypertension.

How Safe is it to Use Tadacip?

Tadacip and other medications under the same category are often called wonder drugs. Their creation changed the whole treatment regimen for ED. It provided ED patients with easily accessible, discreet, and effective treatment measures.

Tadacip is safe for use in most men as a long-term ED medication. But, like most other medications, it can have side effects. Most of its side effects come from taking too much.

Side Effects of Tadacip

Here are some of the common side effects experienced by men who take Tadacip:

Headaches
Flushing
Indigestion
Vision loss
Nasal congestion
Back pain
Dizziness
Abnormal vision
Nausea
Rash
Muscle pain

Drugs That Could Interact With Tadacip

Some medications can interact with Tadacip and increase the risk of adverse effects. It is important to let your doctor know beforehand about other medications you are currently taking or other health problems.

Here are some of the common medications that could react with Tadacip:

Anti-Hypertensive Medications

These are the medications used to lower high blood pressure and include drugs like alpha-blockers, angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers, and angiotensin II receptor blockers. Tadacip can interact with these medications and cause a significant drop in blood pressure.

Nitrates

Nitrates are used to treat angina, coronary artery disease, and heart failure. These include drugs like nitroglycerin, isosorbide dinitrate, etc. Tadacip can interact agonistically with these medications and lower blood pressure.

Guanylate Cyclase (GC) Stimulators

These are medications used to treat pulmonary hypertension and heart failure. Examples of GC stimulators are Riociguat, vericiguat, and others. These can interact with Tadacip agonistically and cause low blood pressure.

CYP3A4 Inhibitor

These include ritonavir, ketoconazole, itraconazole, erythromycin, and others. They can slow down the metabolism of Tadacip in the body and prolong its duration of action.

Alcohol

Tadacip and alcohol may cause symptoms like intense headaches, vomiting, and other unwanted side effects, including some severe ones.

Antacids

Antacids can slow down the uptake of Tadacip in the body. They include medicines such as Alternagel, Mmphojel, Alka-Seltzer, and others.

CYP3A4 Inducers

These canhasten the removal of Tadacip from the body, meaning it will last for a much shorter duration and lessen its effects. These include rifampin, carbamazepine, phenytoin, phenobarbital, and others.

Who Should Avoid Using Tadacip

Certain people must avoid Tadacip altogether, as it can result in life-threatening adverse events. Tadacip should be avoided by people with:

Severe heart conditions
History of non-arteritic anterior ischemic optic neuropathy (NAION) or “crowded” optic disc
Retinitis pigmentosa
Severe allergy to Tadacip
History of priapism
Severe kidney disease
Blood disorders like hemophilia, leukemia, and sickle-cell anemia

Medical Research Involving Tadacip

Multiple studies have been conducted on tadalafil to show how well it can work in treating ED and BPH [1, 2]. In addition, it has also been shown to be effective in treating pulmonary arterial hypertension [3].

However, clinical studies on the brand Tadacip itself have not been conducted. This is because the drug is generated from the same extensively studied formula of tadalafil, making further research unnecessary.

Are There Other Medications Like Tadacip?

There are many different kinds of ED medications, some of which may be more expensive than others. And while some use the same ingredient as Tadacip, others may have different formulas. But overall, they all have a similar mechanism of action.

Here we’ll talk about the pharmaceutical and non-pharmaceutical alternatives to Tadacip.

Pharmaceutical Alternatives

These include drugs that have a similar formulation as Tadacip. Some of these include:

Sildenafil (Viagra, Cenforce, Kamagra, Fildena, P-Force, Vygex, etc.)
Tadalafil (Cialis, Adcirca, Vidalista, Forzest, & more)
Udenafil (Zydena)
Vardenafil (Levitra, Staxyn, Vilitra, Zhewitra, Savitra, & more)
Avanafil (Avaforce, Stendra, Avana)
Mirodenafil (Mvix)

Non-Pharmaceutical Alternatives

These include some methods, natural herbs, and nutrients that may help treat ED. Most of these have little research on them to see how effective they are. If you feel hesitant to try out pharmaceutical drugs, these techniques and herbs may be a good place to start.

Lifestyle Changes to Help With ED

Balanced diet — A good diet will ensure that you get all the nutrients and help with your ED [4].

Sleep —Not getting enough sleep can cause testosterone levels to decrease, so sleep is essential to maintain vitality [5].

Exercise — A healthy and fit body can help regulate testosterone and lower the risk of ED [6].

Stress reduction — Stress can induce many kinds of illnesses. This also includes intake of excess alcohol, smoking cigarettes, etc. To prevent ED, it may be a good idea to do various activities like yoga and meditation [7].

Psychotherapy and sex or couple counseling — Sometimes ED can be due to psychological factors. In this case, it may be a good idea to go for both couples to visit psychological counseling [8].

Natural Herbs to Help With ED

Horny goat weed (Epimedium spp.) — can increase stamina, raise libido, and help in treating ED [9].

Ginseng (Panax ginseng) — can improve libido and stamina and have antioxidant properties [10].

Maca (Lepidium meyenii)— can relieve stress and improve ED [11].

Yohimbe (Pausinystalia johimbe)— is believed to increase penile blood flow and make erections last longer [12].

Mondia whitei — has been found to increase sperm movements and raise testosterone levels [13].

Muira puama (Ptychopetalum olacoides) — increases blood flow to the penis and increases libido [14].

L-Arginine — can increase the blood flow to the penis [15].

Tribulus (Tribulus terrestris) — increases libido, provides energy, and relieves stress [16].

Where to Buy Tadacip

Tadacip is a prescription-only drug in most countries. Once you have a prescription, you can buy Tadacip from a nearby pharmacy or online. Most people prefer the second option as it is easier and is discreet.

If you seek a reliable and long-lasting treatment for ED, Tadacip may be the medication for you, but it’s often best to try natural treatments first. Sometimes, a simple change in lifestyle can be enough to fix the problem.

References

Coward, R. M., & Carson, C. C. (2008). Tadalafil in the treatment of erectile dysfunction. Therapeutics and clinical risk management, 4(6), 1315.
Mónica, F. Z., & De Nucci, G. (2019). Tadalafil for the treatment of benign prostatic hyperplasia. Expert opinion on pharmacotherapy, 20(8), 929-937.
Henrie, A. M., Nawarskas, J. J., & Anderson, J. R. (2015). Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. Core evidence, 10, 99.
Bauer, S. R., Breyer, B. N., Stampfer, M. J., Rimm, E. B., Giovannucci, E. L., & Kenfield, S. A. (2020). Association of Diet With Erectile Dysfunction Among Men in the Health Professionals Follow-up Study. JAMA network open, 3(11), e2021701-e2021701.
Pastuszak, A. W., Moon, Y. M., Scovell, J., Badal, J., Lamb, D. J., Link, R. E., & Lipshultz, L. I. (2017). Poor sleep quality predicts hypogonadal symptoms and sexual dysfunction in male nonstandard shift workers. Urology, 102, 121-125.
Gerbild, H., Larsen, C. M., Graugaard, C., & Josefsson, K. A. (2018). Physical activity to improve erectile function: a systematic review of intervention studies. Sexual medicine, 6(2), 75-89.
Nordin, R. B., Soni, T., Kaur, A., Loh, K. P., & Miranda, S. (2019). Prevalence and predictors of erectile dysfunction in adult male outpatient clinic attendees in Johor, Malaysia. Singapore medical journal, 60(1), 40.
Li H, Gao T, Wang R. The role of the sexual partner in managing erectile dysfunction. Nature Reviews Urology. 2016 Mar;13(3):168-77.
Liu, W. J., Xin, Z. C., Xin, H., Yuan, Y. M., Tian, L., & Guo, Y. L. (2005). Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian journal of andrology, 7(4), 381-388.
De Andrade, E., De Mesquita, A. A., de Almeida Claro, J., De Andrade, P. M., Ortiz, V., Paranhos, M., … & Erdogrun, T. (2007). Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian journal of andrology, 9(2), 241-244.
Shin, B. C., Lee, M. S., Yang, E. J., Lim, H. S., & Ernst, E. (2010). Maca (L. meyenii) for improving sexual function: a systematic review. BMC complementary and alternative medicine, 10(1), 1-6.
Carey, M. P., & Johnson, B. T. (1996). Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Archives of sexual behavior, 25(4), 341-360.
Quasie, O., Martey, O. N. K., Nyarko, A. K., Gbewonyo, W. S. K., & Okine, L. K. N. (2010). Modulation of penile erection in rabbits by Mondia whitei: possible mechanism of action. African Journal of Traditional, Complementary and Alternative Medicines, 7(3).
Ferrini, M. G., Garcia, E., Abraham, A., Artaza, J. N., Nguyen, S., & Rajfer, J. (2018). Effect of ginger, Paullinia cupana, muira puama and l-citrulline, singly or in combination, on modulation of the inducible nitric oxide-NO-cGMP pathway in rat penile smooth muscle cells. nitric oxide, 76, 81-86.
Moody, J. A., Vernet, D., Laidlaw, S., Rajfer, J., & Gonzalez-Cadavid, N. F. (1997). Effects of long-term oral administration of L-arginine on the rat erectile response. The journal of urology, 158(3), 942-947.
Zhang, H., Tong, W. T., Zhang, C. R., Li, J. L., Meng, H., Yang, H. G., & Chen, M. (2019). Gross saponin of Tribulus terrestris improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum. Diabetes, metabolic syndrome and obesity: targets and therapy, 12, 1705.