Tadalift

Tadalift is a medication that treats the symptoms of impotence in men. It improves sexual performance by allowing the user to maintain an erection during sexual intercourse. It contains the active component tadalafil which is a phosphodiesterase-5 inhibitor. It results in blood vessels of the penis becoming dilated and facilitating a proper erection.

Tadalift is available as an oral tablet. Before the use of this drug, it is essential to be informed about the indications, precautions, and mechanism of action.

What is Tadalift? 

Tadalift is a drug that is used to treat impotence or erectile dysfunction. Erectile dysfunction causes an inability to perform sexual intercourse secondary to a failure to maintain an erection. Tadalift is also known by the generic component name tadalafil.  

Tadalift is manufactured by Pfizer, a prominent pharmaceutical and biotechnology company based in the United States. Many drugs and vaccines are produced by this company. The company produces it as an oral medication available in tablet form.

The generic drug tadalafil is also sold under the trade names Cialis, Tadacip and Adcirca. Tadalafil acts by inhibiting the phosphodiesterase-5 enzyme. This drug increases blood flow to the penis by increasing the number of vasodilators in the bloodstream. It counteracts male impotence and allows proper sexual performance. 

It is also used in prostate disease and pulmonary hypertension. It dilates smooth muscles in these diseases to relieve urinary or respiratory symptoms respectively. 

What Is The Dose of Tadalift? 

Tadalift is available as a 20 mg tablet. The oral tablet should be consumed before intended sexual activity and the maximum dose is one 20 mg tablet a day. 

How Long Does it Take for Tadalift To Kick In?

Tadalift is a quick-acting medication. It can show its effect as early as 15 minutes after use. However, in most men, it takes around an hour for the effects of it to kick in.

 How Long Does Tadalift Last?

Tadalift is a very long-lasting medication that allows greater satisfaction for the user. It allows proper sexual performance for half a day to one day. It is sought after for its long duration of action.

How Much Does Tadalift Cost?

Tadalift can be purchased at 0.8 USD for a blister pack of four tablets. It is an inexpensive alternative to several other expensive drugs available in pharmacies.

The History of Tadalift

Tadalafil is the generic name for Tadalift. Tadalafil was initially discovered in 1993. After its discovery, several studies were conducted on it. 

It was later proven to be useful in erectile dysfunction due to the prominent effect of dilating blood vessels. It was authorized for sale and use in the United States in 2003 after successful clinical safety trials. 

Who Should Take Tadalift?

Men who have erectile dysfunction should take Tadalift. It can help to get an erection. It also sustains erection and allows the completion of sexual intercourse. It does not improve arousal or libido but helps in the physiological erection response.

It is used to relieve symptoms such as increased frequency of micturition, urgency, nocturia, and dysuria associated with benign prostate hyperplasia (BPH), a disease that causes urinary tract obstruction secondary to an enlargement of the prostate gland.

Tadalafil is also approved for use in pulmonary hypertension. The main aim of using this drug is to increase exercise tolerance by dilating the blood vessels present in the lungs. 

Is Tadalift Safe?

Tadalift is a safe drug for people without other significant diseases. It can cause an allergic reaction. There are side effects and adverse reactions of this drug that need to be known. Some rare severe reactions can also occur in some individuals. 

Follow the advice of your doctor while using this drug. Visit a hospital if there are any significant side effects of using this medication. 

Common Side Effects of Tadalift

Tadalift has side effects that need to be informed to the user. The major side effects of this drug are listed below. 

• Auditory problems such as hearing loss
• Dizziness
• Flushing 
• Muscle aches resulting in pain in the back, arms or legs
• Nasopharyngitis
• Nasal bleeding and nasal congestion
• Priapism
• Severe sudden hypotension resulting in dizziness and fainting 
• Stomach pain
• Throbbing headache

Potential Drug Interactions With Tadalift

Alcohol

Use of Tadalift with alcohol is not advised. There can be several unwanted side effects.

Blood Pressure Medication

Blood pressure medication and Tadalift both cause a drop in blood pressure. Using them together can cause a very sudden drop in blood pressure and cause the user to faint. Doxazosin and tamsulosin are common alpha-blockers, and amlodipine is a calcium channel blocker.

CYP3A4 Inhibitors

CYP3A4 enzyme is a liver enzyme that metabolizes phosphodiesterase-5 inhibitors. An accumulation of tadalafil within the bloodstream can occur when these drugs are used along with tadalafil. CYP3A4 inhibitors include macrolide antibiotics such as erythromycin and clarithromycin. Other inhibitors are antifungal drugs such as ketoconazole and itraconazole.  

Guanylate Cyclase (GC) Stimulators

Guanylate cyclase (GC) stimulators are drugs used to treat heart failure and pulmonary arterial hypertension. Rociguat and vericiguat are examples of guanylate cyclase stimulators. They are not to be used along with Tadalift.

Other Erectile Dysfunction Medication

Other erectile dysfunction drugs such as sildenafil and vardenafil cause vasodilation. They should not be combined with Tadalift.

Who Should Avoid Using Tadalift

• Patients with ophthalmic disorders such as degenerative eye diseases, ischemic optic neuropathy, and retinitis pigmentosa
• Patients with chronic hepatic disease
• Patients with sensitivity to the chemicals used in the production of Tadalift
• Patients with heart diseases such as valve disorders, left ventricular outflow obstruction, ischemic heart disease
• Patients with blood disorders such as leukemia which is a blood malignancy and sickle cell anemia 
• Patients with renal diseases such as chronic renal failure

How Does Tadalift Work?

Tadalift contains tadalafil, which is an enzyme inhibitor. It causes competitive inhibition of the liver enzyme phosphodiesterase-5. It increases vasodilators in target cells.

It binds to the phosphodiesterase-5 enzyme. This inhibits the enzyme. This results in the decreased breakdown of and prevents the degradation of cyclic guanosine monophosphate (cGMP). 

Vascular smooth musculature is relaxed by cGMP. The relaxed smooth muscles cause the dilation of blood vessels in a structure within the penis known as corpus carvernosum. This allows the user to have an erection and maintain it during sexual activities. 

Some Points to Remember While Using Tadalift 

• Do not combine it with other medication without consulting your doctor 
• Do not consume it multiple times in a day
• Use it as per the prescription and instructions of the prescribing doctor

Medical Research Involving Tadalift

Numerous studies have been conducted regarding the active ingredient present in it Tadalift. Tadalafil is an active ingredient that was discovered in 1993. 

Tadalafil was initially discovered in the laboratory of a pharmaceutical company. The chemical was found to cause the dilation of blood vessels which is called vasodilation. This property of it was used to test its efficacy in the treatment of male impotence and problems with erections. It was then approved in 2003 for use in the United States [1]. 

The approval was granted after research to ensure that it is effective for its indication and it is safe for use by the intended patients. 

Best Tadalift Alternatives

Tadalift has alternatives of the same and different drug classes. They may share a common mechanism of action. Consultation with a doctor is needed to find the best drug for each individual.

Pharmaceutical alternatives:

• SSRIs (Lexapro, Zoloft, Paxil, Prozac)
• Tadalafil and dapoxetine combination (ED Save Plus, Duraplus, Edon-D Tadapox)
• Udenafil (Zudena, Zydena)
• Vardenafil (Levitra, Staxyn)

Natural Tadalift Alternatives

Some herbal preparations and nutritional supplements can help to alleviate erectile dysfunction. These products are easy to use and often tried by patients before using prescription medication. 

Impotence is a complex problem and some people may not see improvement with these herbal and nutritional preparations. These patients may require prescription medication as per the advice of a doctor.

 The major herbal preparations and nutritional supplements used for erectile dysfunction are listed below.

• Catuaba (Trichilia catigua or Erythroxylum Catuaba) — Catuaba (Erythroxylum catuaba):  Catuaba extract stimulates nerves and is an aphrodisiac. It is used in Asian traditional medicine to aid sexual performance. This drug is used to treat male impotence [2].
• Ginseng (Panax ginseng) — Korean red ginseng and other variants of ginseng have been used in various forms to counteract erectile dysfunction. Its use can result in increased penile rigidity, libido and sexual satisfaction in the patient [3]. 
• Muira puama (Ptychopetalum olacoides) — Muira puama is a Brazilian herb. It is found in the Amazon rainforest of Brazil. This herb is a component of several medications that are used in the treatment of erectile dysfunction [4].
• Tribulus (Tribulus terrestris) — This herbal medicine improves sexual function. It affects the hormonal system and increases testosterone levels in the body. It is used for erectile dysfunction and lower urinary symptoms in aging men [5].

Where to Buy Tadalift in 2022

Tadalift is a drug that can be purchased at a pharmacy. It can also be ordered via online portals. It requires a prescription to be bought. 

Users of this drug often prefer to buy it online. Online delivery can ensure anonymous transactions and it may be an easy alternative to traditional shopping at a pharmacy.

References Cited in This Article

1. Coward, R. M., & Carson, C. C. (2008). Tadalafil in the treatment of erectile dysfunction. Therapeutics and clinical risk management, 4(6), 1315–1330.
2. Martins, N. O., de Brito, I. M., Araújo, S., Negri, G., Carlini, E. A., & Mendes, F. R. (2018). Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba). BMC complementary and alternative medicine, 18(1), 172.
3. Choi, H. K., Seong, D. H., & Rha, K. H. (1995). Clinical efficacy of Korean red ginseng for erectile dysfunction. International journal of impotence research, 7(3), 181–186.
4. Srivatsav, A., Balasubramanian, A., Pathak, U. I., Rivera-Mirabal, J., Thirumavalavan, N., Hotaling, J. M., Lipshultz, L. I., & Pastuszak, A. W. (2020). Efficacy and Safety of Common Ingredients in Aphrodisiacs Used for Erectile Dysfunction: A Review. Sexual medicine reviews, 8(3), 431–442.
5. GamalEl Din, S. F., Abdel Salam, M. A., Mohamed, M. S., Ahmed, A. R., Motawaa, A. T., Saadeldin, O. A., & Elnabarway, R. R. (2019). Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study. Urologia, 86(2), 74–78.