Vivanza

Vivanza works similarly to Viagra and is marketed under the trade name Levitra as well. All of these medications enhance blood circulation to the penis to aid with erections.

Before using Vivanza, we’ll go over all you need to know about it.

We will discuss its mechanism of action, price, and where you can buy it.

What is Vivanza?

The active ingredient in Vivanza is vardenafil. It works effectively and is often well tolerated by men with mild to severe ED of varying severity and etiologies.

Several additional brand-name medications, including Staxyn and Levitra, have the same active component, vardenafil. The chemical composition is very similar to that of Viagra in which the active component is sildenafil.

Vivanza helps men with erectile dysfunction regain their ability to get and maintain an erection by increasing blood flow to the penis during sexual excitement. It was created with the primary purpose of treating erectile dysfunction with an oral medication that is both efficient and safe.

What Is The Dose Of Vivanza?

There are three dosages of Vivanza: 5 mg, 10 mg, and 20 mg.

Most patients will initially be prescribed the regular 10 mg dose and then the dose will be increased based on how their response.

You must consult your doctor before beginning this medication.

How Long Does it Take for Vivanza to Kick In?

Levitra takes roughly an hour to start working.

This medication doesn’t automatically cause erections, and won’t function until you are sexually stimulated.

You can also take other measures to boost your libido, such as consuming a nutritious diet, working out often, and engaging in foreplay prior to engaging in sexual activity.

How Long Does Vivanza Last?

Once you take Vivanza, the effects may last for about 4 to 6 hours. Vivanza’s duration of action may be prolonged in some individuals.

How Much Does Vivanza Cost?

Vivanza oral tablets come in packs of different quantities and the pricing differs accordingly.

The price ranges from 7 USD to 16 USD per tablet depending upon the pack size purchased and the strength of the drug.

On average, a pack of 20 tablets will cost around 220 USD.

Who Can Take Vivanza?

Vivanza is only approved for erectile dysfunction. Premature ejaculation therapy and athletic stimulation are two examples of off-label applications, neither of which are approved applications of the drug.

Before you use Vivanza, your doctor may need to modify one or more of your current prescriptions. If so, your doctor may advise switching your prescription first, pausing for a while, and then starting Vivanza once they are certain no adverse health consequences have occurred.

If you have a sexual dysfunction and wish to take Vivanza, make sure to talk to your doctor first to see if you are a good candidate for the drug.

Is Vivanza Safe?

The FDA and other governing bodies generally consider Vivanza to be safe, but like any other drug, there are some potential negative effects.

Vivanza shares the same side effects and safety concerns as other PDE5 inhibitor drugs like Levitra, Cialis, and Viagra. As a result, it is likely that Vivanza will have the same adverse effects that you experience with any of these other prescriptions.

Levitra’s effect on blood pressure is one of the main cause of worry among patients. The medication causes the arteries that provide blood to the penis to relax. It may, however, also impact other arteries. Blood pressure decreases as the arteries loosen up.

Common side effects of Vivanza include:

• Flushing or sweating
• Priapism
• Edema/swelling 
• Nausea 
• Drowsiness
• Headaches 
• Nose blockage
• Abdominal pain
• Problems with vision
• Loss of hearing
• Skin rashes 

Rare but severe side effects of Vivanza include:

There are some rare but potentially harmful effects of Vivanza, which is why its use is prescription-only. Hence, your physician will weigh up all the risks and benefits before prescribing this drug for you.

Prolonged Erection

An erection that lasts four hours or more is considered prolonged. Although this symptom isn’t immediately harmful, if ignored for a prolonged period of time, it can progress to a more serious condition, namely priapism.

Priapism

A prolonged and painful erection that lasts more than six hours is referred to as priapism. Many users don’t know how serious this issue really is. Permanent penile tissue damage from priapism might result in impotence for life.

Allergic reactions and hypersensitivities

After using Vivanza, a tiny fraction of users get a severe rash. Some people react to Vivanza by developing a swollen face and neck, and additionally, breathing difficulties may occur too.

Cardiovascular Disease 

Patients with undiagnosed heart disease could notice a worsening of their symptoms, which might be fatal. During sexual engagement, blood pressure changes and greater physical effort can put stress on the cardiovascular system and cause angina or coronary artery blockage.

Loss of Vision

A few cases of non-arteritic anterior ischemic optic neuropathy (NAION) following Vivanza use have been documented. If not treated right once, this illness, which includes a reduction in blood flow to the eye’s optic nerve, can cause irreversible vision loss.

Loss of hearing

A tiny proportion of Viagra users have reported experiencing an abrupt loss or impairment in hearing. It is challenging to foresee this since it is unclear what causes this outcome.

Potential Drug Interactions With Vivanza

Vivanza and other PDE5 inhibitors don’t interact well with several drugs.

Here are some of the most significant detrimental or dangerous drug interactions to be aware of prior to using Vivanza:

Nitrates

Vivanza may make people feel lightheaded or faint by enhancing the hypotensive effects of nitrate medications. To treat angina, coronary artery disease, and excessive blood pressure, nitrates are frequently utilized.

Alpha-blockers

Alpha-blockers and vasodilators like Vivanza can reduce blood pressure below normal norms. Combining the two drugs can be risky, thus it must be done cautiously and under the supervision of a licensed healthcare professional.

Antihypertensives

Blood pressure may drop extremely low and result in fainting spells while using Vivanza and blood pressure-lowering medications because of their comparable effects.

Alcohol

Serious negative effects including low blood pressure, dizziness, migraines, and an increased heart rate may result when Vivanza is used with alcohol.

Antacids

Magnesium hydroxide and other antacids can drastically reduce the body’s ability to absorb Vivanza, which lowers the drug’s effectiveness.

CYP3A4 Inhibitors

Vivanza is mostly metabolized in the liver by the CYP3A4 enzymes. Taking different drugs that are metabolized by the same enzyme might affect the rate of degradation for Vivanza. The drug’s half-life might be extended as a result, and its bloodstream concentrations could rise.

Some of these include erythromycin, grapefruit juice, and ketoconazole.

CYP3A4 Inducers

Just opposite to CYP3A4 inhibitors, certain medications increase the activity of this enzyme, which speeds up the metabolism of Vivanza and results in shorter or weaker effects.

Some of these include rifampicin, phenytoin, and carbamazepine.

Who Should Avoid Using Vivanza?

Since Vivanza may result in adverse side effects in some people, you should only get it with a legitimate prescription from your physician.

Here are a few examples of people who should avoid using Vivanza:

1. Someone having severe heart disease or heart valve failure
2. Patients with a history of NAION or “crowded” optic disc
3. Patients diagnosed with retinitis pigmentosa
4. Anyone under any of the contraindicated medications listed in the previous section
5. Patients with a history of sildenafil hypersensitivity
6. Anyone with severe kidney disease
7. Patients who have certain blood disorders (hemophilia, leukemia, sickle-cell anemia)

How Does Vivanza Work?

Vivanza (Vardenafil) is a medication used to treat erectile dysfunction. It is a selective inhibitor of phosphodiesterase type 5 that is cyclic guanosine monophosphate (cGMP)-specific (PDE5). The relaxation of the smooth muscle of the corpus cavernosum and the arterioles that are connected to it is what causes the hemodynamic process that leads to penile erection.

Vivanza prevents the phosphodiesterase type 5 (PDE5) enzyme, a particular cGMP phosphodiesterase, from degrading cGMP in the corpus cavernosum, a region around the penis. When a person is sexually stimulated, their penile blood flow increases as a result of the relaxed penile arteries and corpus cavernosal smooth muscle. Nitric oxide (NO), which is released by nerve terminals and endothelial cells, mediates this reaction by inducing the creation of cGMP in smooth muscle cells. 

Increased blood flow to the corpus cavernosum and relaxing of smooth muscles are both effects of cyclic GMP. Vivanza increases cGMP levels by inhibiting phosphodiesterase type 5 (PDE5), which improves erectile function.

Medical Research Involving Vivanza

The use of Vivanza is still off-label and more research will be needed for it to be approved for use.

In the United States and Canada, 54 study centers participated in a study,  which compared vardenafil 5, 10, and 20 mg to a placebo in a phase 3 randomized, double-blind, fixed-dose study.

According to the study’s findings, all the Vivanza doses considerably outperformed a placebo in the treatment of erectile dysfunction [1].

In another double-blind, placebo-controlled prospective trial consisting of 452 patients, the effectiveness and safety of vardenafil therapy for erectile dysfunction (ED) in men with diabetes were assessed (type 1 & 2 both). In these diabetic individuals with ED, Vivanza statistically increased erectile function and was usually well tolerated [2].

Another study discovered that Vivanza is a strong and potent inhibitor of PDE5. Vivanza’s therapeutic effectiveness in treating erectile dysfunction patients has been proven in Phase II studies [3].

Vivanza Alternatives

There are other options for treating erectile dysfunction than Vivanza. For this condition, doctors may recommend a number of well-known drugs that function similarly to Vivanza. The closest is a medication known as sildenafil that is widely known as Viagra.

Additionally, generic versions of Vivanza produced by businesses all around the world are attainable in the market.

Here are some of the most prominent Vivanza alternatives:

• Sildenafil (Viagra)
• Tadalafil (Cialis)
• Avanafil (Stendra)
• Vardenafil (Levitra, Staxyn)
• Mirodenafil (Mvix)
• Udenafil (Zydena)

Are There Any Natural Alternatives to Vivanza?

To replicate the exact effects might be very hard but there are some alternatives to this medication. Some natural compounds can be used to provide results that are comparable to Vivanza for individuals seeking alternatives.

Here are some of the most common natural Vivanza alternatives to consider:

Red Ginseng (Panax quinquefolium)

This study, among many, has shown that red ginseng has positive benefits on erectile dysfunction in terms of improved penile tip stiffness and subjective symptom alleviation [4].

Yohimbe (Pausinystalia johimbe)

Yohimbine is an alkaloid that comes from a tree commonly found in Africa. It has shown positive effects on erectile dysfunction in men. Care must be exercised, though, since it may sometimes be dangerous [5].

L-citrulline

L-citrulline supplementation, which converts to L-arginine in the body has been shown to be safe for a brief period of time, for ED. It can be a good alternative treatment for mild to moderate ED, particularly in individuals who have a psychological aversion to PDE-5 enzyme inhibitors [6].

Where to Buy Vivanza in 2022

Vivanza is a medication that requires a prescription in the US and most countries. 

Your doctor will determine whether Vivanza is appropriate for you after ruling out any underlying medical conditions. 

Then, you may buy Vivanza online or through a nearby drugstore. Online shopping gives customers both privacy and discretion.

References:

1. Hellstrom, W. J., Gittelman, M., Karlin, G., Segerson, T., Thibonnier, M., Taylor, T., & PADMA‐NATHAN, H. A. R. I. N. (2002). Vardenafil for treatment of men with erectile dysfunction: Efficacy and safety in a randomized, double‐blind, placebo‐controlled trial. Journal of andrology, 23(6), 763-771.
2. Goldstein, I., Young, J. M., Fischer, J., Bangerter, K., Segerson, T., Taylor, T., & Vardenafil Diabetes Study Group. (2003). Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes care, 26(3), 777-783.
3. Saenz de Tejada, I., Angulo, J., Cuevas, P., Fernandez, A., Moncada, I., Allona, A., … & Bischoff, E. (2001). The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. International journal of impotence research, 13(5), 282-290.
4. Hong, B., Ji, Y. H., Hong, J. H., Nam, K. Y., & Ahn, T. Y. (2002). A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report. The Journal of urology, 168(5), 2070-2073.
5. Goel, B., & Maurya, N. K. (2020). Aphrodisiac Herbal therapy for Erectile Dysfunction. Archives of Pharmacy Practice, 11(1).
6. Cormio, L., De Siati, M., Lorusso, F., Selvaggio, O., Mirabella, L., Sanguedolce, F., & Carrieri, G. (2011). Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology, 77(1), 119-122.