Sidalist

Sidalist is a drug used in the treatment of erectile dysfunction (ED). It is made up of two drugs: sildenafil citrate and tadalafil. Both drugs are phosphodiesterase 5 inhibitors and help in getting an erection in those men who have ED. 

Before you use Sidalist, you need to know what exactly it is and what it does, and how to use it. We’ll go over these facts in this article. 

What is Sidalist?

Sidalist is a drug for treating erectile dysfunction. Its components consist of sildenafil and tadalafil, two highly effective erectile dysfunction medications in their own right. The combination of these two allows Sidalist to be more potent and effective.

Sildenafil is the base ingredient found in the popular drug Viagra, whereas tadalafil is the base ingredient of Cialis. 

Sidalist is manufactured by Cipla Inc., a multinational pharmaceutical company based in India. 

What’s The Dose of Sidalist?

Sidalist is available in the dosage of 120mg containing 100mg of sildenafil and 10mg of tadalafil. It comes as six tablets in one blister pack. Each tablet is red. The recommended dose is a maximum of one tablet per day or as advised by your physician. 

How Long Does it Take Sildalist To Kick In?

It takes about 15 to 30 minutes for Sidalist to start showing its effects. In first-time users, this time may be lengthened slightly. In such a case, it is best to wait for some time. 

How Long Does Sildalist Last?

Sidalist lasts for about 2 to 3 hours after intake. 

How Much Does Sildalist Cost

It costs about 0.3USD per tablet. This is very inexpensive compared to other erectile dysfunction medications. 

Who Should Take Sildalist?

Sidalist is prescribed to men who have ED. Before prescribing Sidalist, your physician will examine you to rule out any underlying medical issues or drug interactions. If everything goes as planned, they will then prescribe this medication to you based on your requirements.

Depending on how your body responds to the medication, your doctor may change the dosage. One dose per day is the maximum.

Lightheadedness, fainting, and painful and protracted erections may be signs of a Sidalist overdose, whether deliberate or unintentional. In this situation, speak with your doctor right away and get treatment.

The majority of the world’s nations require a prescription to purchase Sidalist. This implies that you can only purchase this medicine after having your ED evaluated by a licensed healthcare expert and receiving a prescription from them.

Sidalist is not recommended for use in children and women. 

Is Sildalist Safe?

Most users tolerate Sidalist rather well. But like most medicines, it also comes with a unique set of side effects. Sidalist should be either taken with caution or avoided completely by those who have cardiac problems, depending on the recommendation of their physician. 

Common Side Effects of Sildalist

• Angina
• Back pain
• Cough
• Diarrhoea
• Flushing
• Headache
• Muscle aches
• Pain in the extremities
• Priapism
• Stomach Upset
• Stuffy or runny nose
• Upper Respiratory Tract Infections
• Vision Disturbances

Potential Drug Interactions With Sildalist

Sidalist and some medications may interact, leading to unintended and potentially harmful adverse effects. Hence,  when these particular drugs interact with the majority of other PDE5 inhibitor treatments, they may cause the same side effects. It implies that if you are unable to take Sidalist, it is likely that you will also be unable to take any other PDE5 inhibitor medications. To prevent using Sidalist with these particular medications, it is best to speak with your doctor beforehand.

Some of the common medications that can interact with Sidalist are:

Nitrates

These drugs are used to treat cardiac diseases like coronary artery disease and angina. Sidalist may interact with these drugs and dramatically reduce blood pressure. Amyl nitrate, nitroglycerin, isosorbide, nitroprusside, and other medications are examples of nitrates.

Alcohol

Any type of alcoholic beverage can trigger serious reactions when used with Sidalist, including headaches, vomiting, drowsiness, and low blood pressure.

Guanylate Cyclase Stimulators

When combined with these medications, Sidalist can work with them to reduce blood pressure levels to very low. These contain drugs like riociguat, which is frequently prescribed to treat pulmonary hypertension.

CYP3A4 Inhibitors

The primary ingredients in Sidalist, sildenafil, and tadalafil, are metabolized by the enzyme CYP3A4. The CYP3A4 enzyme is inhibited by CYP3A4 inhibitors. Sidalist’s elimination from the body can therefore be slowed considerably by combining these two. It, therefore, causes Sidalist’s effects to last longer. Ritonavir, ketoconazole, itraconazole, erythromycin, and other drugs are CYP34A inhibitors.

Medicines for Treating Hypertension

These medications and Sidalist can interact, resulting in a sharp reduction in blood pressure. Alpha-blockers, ACE inhibitors, calcium channel blockers, and angiotensin II receptor blockers are a few examples of such drugs.

CYP3A4 Inducers

When compared to CYP3A4 inhibitors, these drugs operate oppositely. They shorten the half-life of Sidalist in the body and speed up its metabolism. These include phenobarbital, phenytoin, carbamazepine, rifampin, and others.

Antacids

Antacids can decrease the body’s ability to absorb Sidalist, decreasing its effectiveness. Among them are Alternagel, Amphojel, Alka-Seltzer, Tums, Magnesium hydroxide, Gelusil, Maalox, Mylanta, Rolaids, etc.

Who Should Avoid Using Sildalist

• Patients diagnosed with retinitis pigmentosa
• Patients taking any of the contraindicated medications listed in the previous section
• Patients with a history of NAION or “crowded” optic disc
• Patients with a history of priapism
• Patients with a history of Sidalist hypersensitivity
• Patients with certain blood disorders (hemophilia, leukemia, sickle-cell anemia)
• Patients with severe heart disease or heart valve failure
• Patients with severe kidney disease

How Does Sildalist Work

Sidalist contains two base drugs: sildenafil and tadalafil. Both of them belong to the phosphodiesterase 5 inhibitors class. 

They both function by enhancing blood flow in the arteries supplying the corpora cavernosa, the erectile part of the penis. The penis, corpora cavernosa, platelets, skeletal muscles, and vascular, and visceral muscles are the most common locations where PDE5 is found.

Normally, following sexual arousal, the pelvic area’s nerves are activated. Nitric Oxide (NO) will then start to circulate in and around the smooth muscles of corpora cavernosa and penile arteries. Cyclic guanosine monophosphate is a chemical that is increased by nitric oxide (cGMP). It causes the corpora cavernosa and penile smooth muscles to relax as well as an increase in blood flow to the penis. Finally, an erection occurs. 

In the majority of ED patients, these arteries are damaged and dysfunctional. Additionally, PDE5 prevents cGMP from working as it should in ED patients, preventing the smooth muscles of the penis from relaxing. As a result, there is improper blood flow into the penis. Consequently, there is no erection.

The sildenafil component of this drug helps to achieve an erection following sexual stimulation. Erection happens as a result of its action, which causes a significant increase in the bloodstream level of the genitals. Tadalafil works to prolong erection during sexual activity by enhancing the effects of sildenafil. Patients can get erect as soon as 15 to 20 minutes after taking the medication thanks to this special fusion of two active components.

Medical Research Involving Sildalist

The sildenafil component of Sidalist is effective in treating erectile dysfunction and pulmonary hypertension [1,2]. Tadalafil is effective in the treatment of erectile dysfunction, benign prostate hyperplasia, and pulmonary hypertension [3,4,5]. Though there is some research on the individual drugs of this medication, there isn’t much research conducted on the effects of the combination drug itself. 

Best Sildalist Alternatives

ED can be treated with many different drugs. They might contain some type of ingredient that functions similarly to Sidalist’s active ingredient, or they may have other components. However, all of them give the same result, that is, to cause an erection. 

Pharmaceutical Alternatives

There are many other alternatives for Sidalist. Some of these might cost less, while others might cost more. Nevertheless, they all work similarly.

Other branded drugs that can work the same as Sidalist are:

• Sildenafil (Viagra, Cenforce, Kamagra, Fildena, P-Force, Vygex, & more)
• Tadalafil (Cialis, Adcirca, Vidalista, Tadacip, Forzest, & more)
• Avanafil (Avaforce, Stendra, Avana)
• Mirodenafil (Mvix)
• Udenafil (Zydena)
• Vardenafil (Levitra, Staxyn, Vilitra, Zhewitra, Savitra, & more)

Natural Sildalist Alternatives

Sidalist has a few natural substitutes as well. Herbs and several nutrients are among them. However, the majority of them lack enough clinical testing and sufficient research to demonstrate their efficacy.

However, if you are afraid to attempt prescription medications directly, these complementary and alternative treatments might be a good starting point. You can advance to pharmaceutical drugs if they don’t work.

A few alternative herbs and supplements for the treatment of ED are listed below:

Horny goat weed (Epimedium spp.) — These herbs produce an enzyme called icariin that has the same capacity to inhibit PDE5 as Sidalist. Joint aches, erectile dysfunction, and poor libido can be treated with horny goat weed [6].

Ginseng (Panax ginseng) — This herb has been suggested to be effective in treating ED as well as several other conditions and health conditions such as regulating blood sugar levels, strengthening the immune system, enhancing brain function, and reducing fatigue [7].

Muira Puama (Ptychopetalum olacoides) — This is a herb that improves sexual arousal and can help to reduce the symptoms of ED [8]. The corpora cavernosa, which acts like a sponge and retains blood during an erection, is relaxed by this herb. Because of the increased blood flow to the penis brought on by this relaxation, the erectile response is better.

L-arginine — This amino acid produces nitric oxide. The NO can then assist in the production of cGMP, assisting in ED [9].

Catuaba (Trichilia catigua or Erythroxylum Catuaba) — ED and low libido may be treated with catuaba [10]. They can also improve sexual functions. 

Yohimbe (Pausinystalia johimbe) — Yohimbe can be used to treat ED and boost sexual arousal [11]. Yohimbine affects the body by inhibiting receptors known as alpha-2 adrenergic receptors.  These receptors are crucial in preventing erections. Yohimbine is therefore believed to treat erectile dysfunction by inhibiting the receptors that impede erections. Nitric oxide may be released more readily when yohimbine is used. This can cause blood vessels to swell in the penis, leading to penile erection. 

Where to Buy Sildalist in 2022

To use Sidalist, you must first get a prescription from your physician since it is a prescription-only medication. After receiving it, you can purchase it online or from any nearby pharmacy. It is preferable to purchase them online because it is more covert and eliminates the headaches of going shopping.

It is advisable to look around and choose what is best for you because there are alternative less expensive generic medications.

Sidalist may be the best medication for treating your erectile dysfunction. 

References Cited in This Article

1. Hatzimouratidis, K. (2006). Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clinical interventions in aging, 1(4), 403.
2. Barnett, C. F., & Machado, R. F. (2006). Sildenafil in the treatment of pulmonary hypertension. Vascular health and risk management, 2(4), 411.
3. Coward, R. M., & Carson, C. C. (2008). Tadalafil in the treatment of erectile dysfunction. Therapeutics and clinical risk management, 4(6), 1315.
4. Mónica, F. Z., & De Nucci, G. (2019). Tadalafil for the treatment of benign prostatic hyperplasia. Expert opinion on pharmacotherapy, 20(8), 929-937.
5. Henrie, A. M., Nawarskas, J. J., & Anderson, J. R. (2015). Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. Core evidence, 10, 99.
6. Liu, W. J., Xin, Z. C., Xin, H., Yuan, Y. M., Tian, L., & Guo, Y. L. (2005). Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian journal of andrology, 7(4), 381-388.
7. De Andrade, E., De Mesquita, A. A., de Almeida Claro, J., De Andrade, P. M., Ortiz, V., Paranhos, M., … & Erdogrun, T. (2007). Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian journal of andrology, 9(2), 241-244.
8. Ferrini, M. G., Garcia, E., Abraham, A., Artaza, J. N., Nguyen, S., & Rajfer, J. (2018). Effect of ginger, Paullinia cupana, Muira puama, and l-citrulline, singly or in combination, on modulation of the inducible nitric oxide-NO-cGMP pathway in rat penile smooth muscle cells. nitric oxide, 76, 81-86.
9.  Moody, J. A., Vernet, D., Laidlaw, S., Rajfer, J., & Gonzalez-Cadavid, N. F. (1997). Effects of long-term oral administration of L-arginine on the rat erectile response. The journal of urology, 158(3), 942-947.
10. Lim, P. H. (2017). Asian herbals and aphrodisiacs are used for managing ED. Translational andrology and urology, 6(2), 167. https://pubmed.ncbi.nlm.nih.gov/28540223/
11.  Carey, M. P., & Johnson, B. T. (1996). Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Archives of sexual behavior, 25(4), 341-360.