Dulata

A serotonin-norepinephrine reuptake inhibitor (SNRI) Dulata is used to treat osteoarthritis, stress incontinence, neuropathic pain, generalised anxiety disorder, fibromyalgia, depression, and diabetic nerve pain.

It contains the active ingredient duloxetine and works by inhibiting the reuptake of serotonin and norepinephrine in the brain.

Concerning Dulata, there are a few things you need to be aware of.

In this article, we’ll go over them in further detail.

What is Dulata?

Dulata is the brand name of the drug duloxetine. It is a medication belonging to the serotonin and norepinephrine reuptake inhibitor (SNRI) class.

Dulata is a product of Healing Pharma, a pharmaceutical company based in India.

Dulata is used in the treatment of various conditions. These include osteoarthritis, stress incontinence, neuropathic pain, generalised anxiety disorder, fibromyalgia, depression, and diabetic nerve pain.

Dulata works by inhibiting the reuptake of serotonin and norepinephrine. This helps it in expressing its pain-relieving, and anxiolytic properties.

What is the Dose of Dulata?

Dulata comes in three different doses:

20 mg
30 mg
60 mg

Dulata is a round-shaped pill that is packaged in a ten-tablet packet. It costs about $0.19 per 60mg tablet.

In most countries, Dulata is only available with a prescription. So you need to get checked by your physician and get a prescription for it before you can procure it.

How Long Does it Take for Dulata to Work?

Dulata takes two to four weeks to start working. To fully take effect, it can take a few weeks or months.

How Long Does Dulata Last?

After consuming the last dose, within 12 hours on average, 50% of the duloxetine will have exited the body, with a range of 8 to 17 hours.

Who Can Take Dulata?

Dulata can be consumed by anyone who has a generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence.

However, if you have recent (within two weeks) therapy with monoamine oxidase (MAO), consuming Dulata may be detrimental to your health.

Can You Take Dulata With Alcohol?

Dulata cannot be taken with alcohol as doing so can lead to liver damage, can worsen side effects, and may make Dulata less effective in treating anxiety. As a result, it is not suggested for use with alcoholic beverages.

How Do You Take Dulata?

40 to 60 mg of Dulata per day, administered once daily or in divided doses twice a day, is the recommended dosage for major depressive disorder. It takes four to eight weeks of therapy at the suggested dosage to get a result.

The History of Dulata

Eli Lilly and Company discovered duloxetine in 1993 and named it LY248686.

For the treatment of Major Depressive Disorder, duloxetine was initially given FDA approval in August 2004 under the brand name Cymbalta. The US patent on Cymbalta expired on 11 December 2013.

After its expiration, other pharmaceutical companies have since begun to produce it at a lesser cost. Healing Pharma began producing it following the end of this patent.

How Does Dulata Work?

Dulata works by inhibiting the reuptake of serotonin and norepinephrine (NE) in the central nervous system. Duloxetine also boosts dopamine levels in the prefrontal cortex. The process causing the rise in dopamine levels involves blocking norepinephrine transporters. These transporters can function on both dopamine and norepinephrine because of their high affinity for dopamine. Therefore, inhibiting norepinephrine transporters can boost dopamine levels. Dopamine transporters are scarce in the prefrontal cortex, where norepinephrine transporters dominate reuptake, thus, this increase in dopamine is found there.

By inhibiting NE reuptake pumps (NET), which are thought to mediate the reuptake of dopamine and NE, duloxetine raises the former’s levels. This specifically occurs in the prefrontal cortex, which has few dopamine reuptake pumps.

Duloxetine can be thought of as a selective reuptake inhibitor at the 5-HT and NE transporters because it has no distinct affinity for dopaminergic, cholinergic, histaminergic, opioid, glutamate, or GABA reuptake transporters.

In comparison to other reuptake inhibitors, duloxetine also appears to be reasonably well tolerated and to have fewer side effects.

It is useful for fibromyalgia as well. It functions by preventing serotonin and norepinephrine from re-entering cells, which raises the levels of these chemicals. Patients with fibromyalgia who undergo this process report feeling happier and having less pain.

It is believed that an improved urethral contraction and persistent sphincter tonus during the filling phase are the causes of the clinical effectiveness of duloxetine treatment in women with stress urinary incontinence.

How Safe is Dulata?

Dulata is safe to take in most cases. However, like most medications, dulata generally impacts the whole body itself. As a result, it might have certain unfavorable effects. While most of them are minor, a few could be fatal. Overdosing, taking the incorrect dose, or combining it with other drugs are common causes of these negative effects.

Side Effects of Dulata

Here are some of the common side effects of Dulata.

Abdominal pain
Abnormal dreams
Agitation
Anorexia
Anxiety
Blood pressure increase
Blurred vision
Constipation
Cough
Decreased appetite
Decreased libido
Diarrhoea
Dizziness
Dry mouth
Dyspepsia
Dysuria
Ejaculation delayed
Erectile dysfunction
Fatigue
Gastritis
Headache
Hot flushes
Hyperhidrosis
Influenza
Insomnia
Male sexual dysfunction
Muscle spasms
Musculoskeletal pain
Nasopharyngitis
Nausea
Oropharyngeal pain
Palpitations
Paresthesia
Rash
Somnolence
Tremor
Upper respiratory tract infection (URTI)
Vomiting
Weight loss

Medications That Can Interact With Dulata

Dulata and other medications may interact, causing unfavorable side effects. So, let your physician know in advance if you’re taking any of these medications. Most other SNRI drugs will likely react similarly if you’re taking a prescription that interacts with Dulata because they all function in the same way.

Dulata and the following medicines may interact:

MAOIs

Dulata should not be used with monoamine oxidase inhibitors (MAOIs) or even within 14 days of using the latter.

This is because combining SNRIs and MAOIs can cause dangerous, occasionally deadly side effects such as extremely high body temperatures, muscle rigidity, rapid changes in blood pressure and heart rate, intense agitation that can develop into delirium, and coma. Examples of MAOIs are isocarboxazid (Marplan), phenelzine (Nardil), and selegiline (Emsam).

SSRIs

Dulata and selective serotonin reuptake inhibitors (SSRIs) should not be used together as doing so may reduce platelet aggregation and raise the risk of bleeding incidents, including gastrointestinal hemorrhage, ecchymoses, hematomas, epistaxis, and petechiae. Examples of SSRIs are citalopram (Cipramil), dapoxetine (Priligy), and escitalopram (Cipralex).

Antipsychotics

Dulata should not be used with antipsychotics as their combinations have the potential to cause side effects such as extremely high body temperatures, tight muscles, rapid changes in blood pressure and heart rate, delirium-like symptoms, and coma. Examples of antipsychotics are risperidone (Risperdal), quetiapine (Seroquel), olanzapine (Zyprexa), ziprasidone (Zeldox), paliperidone (Invega), aripiprazole (Abilify) and clozapine (Clozaril).

Inhibitors of the CYP2D6 enzyme

Drugs such as bupropion, fluoxetine, paroxetine, quinidine, and terbinafine are inhibitors of the CYP2D6 enzyme. CYP2D6 can metabolize Dulata; therefore, combining it with the inhibitors of this enzyme may prolong the time the drug remains in the body by making it take longer to exit the system.

Inducers of CYP2D6

In contrast to CYP2D6 inhibitors, inducers facilitate the body to break down Dulata more quickly. Some of them include corticosterone and dexamethasone.

NSAIDS

Because Dulata itself is linked to bleeding, using it with aspirin, NSAIDs like ibuprofen, and nimesulide may increase the risk of bleeding.

Anticoagulants

Anticoagulants like warfarin (Coumadin), or other medications that are also linked to bleeding should not be used with Dulata as it may worsen the bleeding.

Who Should Not Use Dulata?

There are certain conditions where Dulata should not be used. These are:

Patients with a history of mania
Patients with cardiac disease, hypertension, hypotension, orthostatic hypotension, syncope
Patients with suicidal thoughts
Patients with uncontrolled closed-angle glaucoma
Patients with a seizure disorder

Medical Research Involving Dulata

There is research regarding duloxetine, the key ingredient of Dulata. It is used in the treatment of fibromyalgia [1]. Duloxetine is used in the treatment of generalized anxiety disorder [2]. Diabetic peripheral neuropathy may be treated with duloxetine at a dosage of 60 mg daily [3]. For knee osteoarthritis that has not responded to acetaminophen or nonsteroidal anti-inflammatory drugs, duloxetine is a second-line treatment [4].

Duloxetine has been shown to be effective in reducing incontinence episodes and improving quality of life [5].

Studies conducted on this medicine from the specific company, however, are limited. This is so because the majority of companies employ the same formula and manufacturing process to create medicine. They, therefore, have little need to undertake their study.

Are There Any Alternatives to Dulata?

The diseases that Dulata is used to treat can be treated with a wide range of medications. The majority are drugs that have FDA approval and could have the same active ingredient as Dulata. It might be a good idea for you to check about it as a result.

Pharmaceutical Alternatives

Dulata is a name-brand medication. Other medications that work similarly to this one are widely available. While some of them might be expensive, others might not.

The following are some Dulata substitutes:

Atomoxetine (Strattera)
Desvenlafaxine (Pristiq, Khedezla)
Levomilnacipran (Fetzima)
Milnacipran (Savella)
Venlafaxine (Effexor XR)

Natural Alternatives

Herbs and nutrients are among them. Most of them are traditional things about which little investigation has been done. It may be a good idea to start with natural medications if you’re hesitant to try out prescription medicines at first. You can always go back to taking prescription medications if these alternative therapies do not help you.

The following are some of the herbs and nutrients that may help in treating generalised anxiety disorder:

Ashwagandha (Withania somnifera) — This herb can reduce stress, decrease anxiety and improve sleep [6].

Chamomile (Matricaria chamomilla) — Chamomile can help reduce the symptoms of anxiety and depression [7].

Valerian (Valeriana officinalis) — Valerian can help in the treatment of insomnia and anxiety [8].

Magnesium — Magnesium has antidepressant and anxiolytic properties [9].

Omega-3 — Omega-3 Supplements can help to decrease anxiety and stress [10].

Where to buy Dulata in 2023?

Dulata is often only accessible via prescription. You can visit your neighborhood drugstore or get it online if you have a prescription. The latter is the better choice because it is simpler and more covert.

The most successful treatment for neuropathic pain and generalized anxiety disorder may be dulata.

References Used

Acuna, C. (2008). Duloxetine for the treatment of fibromyalgia. Drugs Today (Barc), 44(10), 725-34.
Wright, A., & VanDenBerg, C. (2009). Duloxetine in the treatment of generalized anxiety disorder. International Journal of General Medicine, 2, 153.
Ormseth, M. J., Scholz, B. A., & Boomershine, C. S. (2011). Duloxetine in the management of diabetic peripheral neuropathic pain. Patient preference and adherence, 5, 343.
Osani, M. C., & Bannuru, R. R. (2019). Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis. The Korean Journal of internal medicine, 34(5), 966.
Jost, W. H., & Marsalek, P. (2005). Duloxetine in the treatment of stress urinary incontinence. Therapeutics and Clinical Risk Management, 1(4), 259.
Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of the ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus, 11(12).
Amsterdam, J. D., Li, Q. S., Xie, S. X., & Mao, J. J. (2020). The putative antidepressant effect of chamomile (Matricaria chamomilla L.) oral extract in subjects with comorbid generalized anxiety disorder and depression. The Journal of Alternative and Complementary Medicine, 26(9), 815-821.
Becker, A., Felgentreff, F., Schröder, H., Meier, B., & Brattström, A. (2014). The anxiolytic effects of a Valerian extract is based on valerenic acid. BMC complementary and alternative medicine, 14(1), 1-5.
Poleszak, E., Szewczyk, B., Kędzierska, E., Wlaź, P., Pilc, A., & Nowak, G. (2004). Antidepressant-and anxiolytic-like activity of magnesium in mice. Pharmacology Biochemistry and Behavior, 78(1), 7-12.
Zemdegs, J., Rainer, Q., Grossmann, C. P., Rousseau-Ralliard, D., Grynberg, A., Ribeiro, E., & Guiard, B. P. (2018). Anxiolytic-and antidepressant-like effects of fish oil-enriched diet in brain-derived neurotrophic factor deficient mice. Frontiers in neuroscience, 12, 974.