Manly

Manly is a 100 mg medication with sildenafil citrate as the active ingredient.It is used to manage the symptoms of erectile dysfunction.

In this article, Manly’s mechanism of action, benefits, and side effects will be discussed in detail. We’ll also look at how it compares to other medications with sildenafil and alternative natural treatments.

Let’s get started!

What is Manly?

Manly, produced by Cooper Pharmaceuticals, belongs to the class of PDE5 inhibitors and sex stimulants that contain sildenafil citrate as the active ingredient.

This medication is a potent inhibitor of the cGMP-specific PDE5 enzyme, which helps increase the blood flow to the penile corpora cavernosa to treat erectile dysfunction [1].

Manly is a prescription-only drug that is widely available in both online and local pharmacies. It is similar to Viagra, as they both share the same active ingredient and have a similar mechanism of action. However, Manly is also used to treat pulmonary artery hypertension (PAH) more frequently than Viagra [2].

Manly is metabolized in the liver through the action of the enzyme belonging to the cytochrome CYP450 enzyme family, namely, CYP3A4. It is also metabolized by CYP2C9 in the liver. However, this enzyme is not the major enzyme required for the metabolism of the drug.

After metabolization, the drug and its metabolites aremostly excreted into the feces — almost 80%. About 13% of the remaining 20% is excreted through urine. The remaining is cleared out through other mechanisms.

What’s the Dose of Manly?

Manly is a widely used medication that is available in one single dose of 100 mg. Sildenafil citrate, the active ingredient of Manly, is available in different dosages ranging from 25 to 100 mg.

Hence, Manly has the highest dose of its active ingredient, making it more potent than other low-dose options available on the market.

As the dosage of Manly is on the higher side, it should only be used as prescribed by the physician. Changing the dosages or overdosing to compensate for a missed dose is not recommended, and doing so can have life-threatening complications. Manly should only be used once per day, preferably at the same time to avoid any gastric discomfort or other adverse effects.

Since Manly is a potent medication, it is recommended to take only half a pill at the beginning of the early phases of the treatment. This is to avoid any adverse reactions from developing and allow the body time to adapt to the effects of the medication.

Starting the medication at the lowest possible dose is recommended, and physicians often gradually increase the dose or maintain it, depending on the extent of erectile dysfunction and the effects.

How Long Does It Take For Manly to Kick In?

Manly is a fast-acting medication that begins to show its effects about 20 to 40 minutes after ingestion. If sexual stimulation is applied during this time, it will result in an erection. However, it is important to note that Manly cannot produce a spontaneous erection without appropriate sexual arousal.

How Long Does Manly Stay In Your System?

Manly stays in the system for approximately 36 hours and takes around 96 hours to be virtually undetectable in the system. An important distinction to make here is that even though Manly may last for 36 hours in the body, this does not equate to a 36-hour long erection.

If sexually stimulated during these 36 hours, an erection can occur. However, the erection won’t last as long as the drug is in the system.

In fact, if an erection lasts for longer than 4 hours with consumption of Manly, it is considered to be a medical emergency that requires immediate medical intervention.

How Much Does Manly Cost?

Manly is an affordable medication that can be easily purchased online and locally. The unit price of the medication differs based on the number of pills being purchased at a given time.

The unit price of a Manly pill ranges between$2.10 to $3.18. A box of 10 to 80 pills costs between $31.77 and $254.16, respectively.

How Does Manly Work?

Manly’s mechanism of action is dependent on the cGMP-specific PDE5 inhibition by sildenafil citrate. PDE5 is a potent enzyme found in the walls of the blood vessels all over the body, including the penis.

The main function of the PDE5 enzyme is vasoconstriction and to increase blood pressure in the vessels while decreasing the blood flow through the vessels. Inhibition of this enzyme is how the medication can increase the blood flow through the vessels, especially those around corpora cavernosa.

As erectile dysfunction is mostly the result of poor blood flow through the penile blood vessels, increasing the blood flow is considered to be the best method of treating erectile dysfunction.

Who Can Take Manly?

Manly is prescribed to men with sexual disorders, namely, erectile dysfunction, and cannot be used to treat other sexual disorders. It is not prescribed to the female population or children and adolescents under the age of 18 years.

It is also prescribed for the treatment of pulmonary artery hypertension (PAH), for which the dosages may vary greatly. Often, a physician will prescribe Manly to PAH patientsand recommend using it three times a day, unlike once per day with ED.

Manly can be prescribed to healthy, adult males over the age of 18 who are suffering from ED. However, caution should be taken when using Manly if you have other conditions such as heart disease. The medications used for their treatment, along with the disorder itself, may interact with Manly. These interactions produce adverse effects of major clinical significance and, if left untreated, can be quite fatal.

Is Manly Safe?

Manly is a relatively safe prescription-only medication that has received approval from the FDA and the European Health Services Authority. The sildenafil citrate in Manly and other PDE5 inhibitors is approved in many Asian countries, especially India.

The medication does not have any reported toxicities and adverse effects in the absence of a drug-to-drug or disorder-associated interaction. If proper precautions are taken and the medication is prescribed and used correctly, Manly is safe.

Common Side Effects of Manly

Manly is a medication and, as such, has certain side effects and complications associated with it. However, these are mostly self-limiting, meaning they will resolve spontaneously without any medical intervention.

The common side effects of Manly include:

Bloody and frothy urine
Bloody nose
Burning sensation in the arms and feet
Changes in vision
Diarrhea
Dizziness
Flushing
Headaches that persist for a long time
Indigestion and heartburn
Numbness of the arms and feet
Painful urination
Painful and prolonged erection
Priapism
Sensitivity to light (Photophobia)
Tingling sensation in the limbs

Manly is contraindicated in some patients with certain medical conditions, such as:

Cardiovascular diseases
Hypertension
Kidney disease
Retinitis Pigmentosa

Moreover, this medication should not be used by pregnant women, children, or anyone undergoing surgery or a dental procedure. It is also not recommended to use Manly if another medication containing sildenafil citrate as an active agent is being used.

Potential Drug Interactions With Manly

Manly can interact with several other drugs and medications, all belonging to different classes of drugs. These interactions are usually of major clinical significance as the adverse effects produced due to these interactions require immediate medical intervention.

Common drugs that can interact with Manly are mentioned below.

Alcohol

Alcohol has the same effect on Manly as it does on most other medications. If taken together, alcohol intensifies the side effects of Manly, potentially resulting in prolonged, painful erections. It is not recommended to take Manly and consume alcohol at the same time.

Antacids

These medications are one of the most commonly used over-the-counter drugs as they are widely available and do not require a prescription. However, antacids can interact with sildenafil citrate in Manly and reduce its efficiency. Although the net effect is not systemic or life-threatening, the combination of these medications is still not recommended.

Anti-Hypertensives

Antihypertensives are a group of drugs mainly used to manage high blood pressures through the action of the medication on cells in the walls of the blood vessels. These vessels dilate to decrease blood pressure, and this mechanism of action is quite similar to Manly. As a result of having similar net effects — vasodilation and decreased blood pressure — using them together could result in low blood pressure that has fatal consequences.

CYP3A4 Inducers

This group of drugs includes phenobarbital, phenytoin, and rifampin. All of these drugs increase the effects of the CYP3A4 enzyme, which is also the enzyme responsible for the metabolization and clearance of Manly from the system. Taking these medications together results in increased excretion of the latter due to the former’s positive effect on the enzyme, resulting in the increased functioning ability of the enzyme. However, increased clearance also meansdecreased efficacy of Manly.

CYP3A4 Inhibitors

Much like CYP3A4 inducers, this group of drugs should not be used with Manly. These drugs inhibit the functioning of the enzyme, hence reducing its clearance from the system, which further results in prolonged effects of Manly. These effects could be harmful as prolonged vasodilation and decreased pressure can be fatal if not treated immediately and appropriately.

Guanylate Cyclase Stimulators

These medications are commonly used for treating pulmonary artery hypertension, much like Manly itself. However, combining these two medications increases the risk of lowering pulmonary blood pressure to dangerously low levels. This is why the combination of these medications is not recommended.

Nitroglycerin

Nitroglycerin is used to treat angina, a type of chest pain arising from decreased oxygen supply to the muscles. It works by increasing the blood flow to the muscles, similar to sildenafil citrate in Manly. However, due to similarities in their functions, taking them together could significantly reduce blood pressure and, hence, is not recommended.

Pharmaceutical Alternatives to Manly

There are many other medications with either sildenafil as their active ingredient or other sildenafil-like compounds that can be used to treat erectile dysfunction. These include:

Sildenafil (Viagra, Fildena, P-Force, Vygex)
Tadalafil (Cialis, Tadagra, Tadovas, Tadact,Tadacip, Tadalip)
Avanafil (Avaforce, Stendra, Avana)
Mirodenafil (Mvix)
Udenafil (Zydena)
Vardenafil (Levitra, Vilitra, Savitra)
Alprostadil Injections

Natural Alternatives to Manly

Traditional medicine has always used natural compounds such as tree bark and roots as treatment options for erectile dysfunction [3]. While these medical practices are not so common in today’s day and age, they’re still common, especially as people look for natural ways to treat health issues.

If you struggle with ED, you might want to consider one of these options before starting a prescription. Of course, you still need to be careful if you’re on other medications or supplements since these can still cause an interaction.

These natural compounds are often used for ED:

Yohimbe [4]
Ginkgo Biloba [5]
Horny Goat Weed [6]

Some studies recommend their use as supplements for men who have erectile dysfunction as they are hypothesized to have PDE5 inhibiting properties, similar to sildenafil citrate and Manly. However, further research is necessary to confirm their role in ED treatment.

Where to Buy Manly?

Manly is a prescription-only medication that can be purchased online or from local pharmacies. Most people choose to buy them online due to the ease of the process and the discretion provided by online shopping.

If you’re interested in natural treatments, ask your doctor about implementing them.

References

Goldstein, I., Burnett, A. L., Rosen, R. C., Park, P. W., & Stecher, V. J. (2019). The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction. Sexual medicine reviews, 7(1), 115–128.
Bhogal, S., Khraisha, O., Al Madani, M., Treece, J., Baumrucker, S. J., & Paul, T. K. (2019). Sildenafil for Pulmonary Arterial Hypertension. American journal of therapeutics, 26(4), e520–e526.
Sin, V. J., Anand, G. S., & Koh, H. L. (2021). Botanical Medicine and Natural Products Used for Erectile Dysfunction. Sexual medicine reviews, 9(4), 568–592.
Riley A. J. (1994). Yohimbine in the treatment of erectile disorder. The British journal of clinical practice, 48(3), 133–136.
Yeh, K. Y., Wu, C. H., & Tsai, Y. F. (2012). Noncontact erection is enhanced by Ginkgo biloba treatment in rats: role of neuronal NOS in the paraventricular nucleus and sacral spinal cord. Psychopharmacology, 222(3), 439–446.
Shindel, A. W., Xin, Z. C., Lin, G., Fandel, T. M., Huang, Y. C., Banie, L., Breyer, B. N., Garcia, M. M., Lin, C. S., & Lue, T. F. (2010). Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. The journal of sexual medicine, 7(4 Pt 1), 1518–1528.