Mvix

Mvix is a medication that contains mirodenafil as its active ingredient. It is a phosphodiesterase type 5 inhibitor used to treat erectile dysfunction.

There are some things you should know before you use Mvix, such as what this medication is, what it does, and how it can treat erectile dysfunction. This article explains all of these in detail.

Let’s get right into it.

What is Mvix?

Mvix is a newer phosphodiesterase type 5 (PDE5) inhibitor containing the active ingredient mirodenafil. It is manufactured by SK Chemicals Co., Ltd, a large pharmaceutical company based in South Korea.

It is used in the treatment of erectile dysfunction (ED). Erectile dysfunction is a condition where men are unable to get an erection, even when sexually aroused. It is a condition many men face and are hesitant to talk about.

The underlying cause of ED is not well-understood, but several factors have been implicated, such as poor blood flow, nerve injuries, metabolic diseases, and psychological issues. Regardless of the cause, most medications used in treating ED target the enzyme PDE5.

Likewise, Mvix can help treat ED by acting on the PDE5 enzymes. By inhibiting this enzyme, Mvix allows proper blood flow into the penile arteries, which in turn helps initiate and sustain an erection following sexual stimulation.

What’s the Dose of Mvix?

Mvix is available in two doses:

50 mg
100 mg

It is available in blister packs containing two pills per pack.

Mvix needs to be taken orally about 1 hour before sexual intercourse. The maximum dose of Mvix is one pill per day. Consuming more than one pill a day can increase the risk of adverse effects.

Mvix is a ‘use only when needed’ kind of drug. Mvix should only be taken prior to sexual intercourse. Otherwise, there is no need for daily intake.

How Long Does it Take Mvix To Kick In?

It takes about 30 minutes to 1 hour for Mvix to start working. For first-time users, it may take a bit longer.

How Long Does Mvix Last?

Mvix has a half-life of approximately 2.5 hours. It can last up to 4 to 5 hours after being consumed.

The History of Mvix

After the development of the first PDE5 inhibitor, sildenafil, research on other drugs with similar abilities began. Mirodenafil, the chief ingredient of Mvix, was launched in November 2007 in South Korea.

Then, in December 2011, its orally dissolving film, Mvix S, was launched. It has been approved for use only in Korea for now.

Mirodenafil has more affinity for PDE5. It appears to be ten times more selective for PDE5 than other ED medications like sildenafil.

Who Should Take Mvix?

Mvix is recommended for men with erectile dysfunction. It is designed for men who cannot initiate or maintain an erection. It is a prescription-only drug.

After completing an assessment of your general health status with a certified physician, you can get a prescription for Mvix.

Is Mvix Safe?

Mvix is generally well-tolerated. But like most drugs, it too has some risk of side effects. These side effects usually occur in patients who take doses higher than recommended.

Although most side effects of Mvix are temporary, some can have serious consequences. Therefore, it is important to always follow your doctor’s instructions while using this medication and be on the lookout for any abnormal side effects. If you suffer from any unusual side effects after taking this drug, contact your doctor immediately.

Some possible side effects of Mvix are:

Abnormal vision
Back pain
Dizziness
Headaches
Hot flushes
Muscle pain
Nasal congestion
Nausea
Rash
Sensitivity to light
Stomach upset
Tingling sensation
Vision Loss

Potential Drug Interactions With Mvix

Some medications may react with Mvix if consumed together. If you are taking any of the following medications, you must consult your doctor before starting Mvix. Some of the interactions could be mild, while some may be more serious, so get a consultation from your doctor beforehand.

If you are unable to take Mvix due to the risk of interaction with these medications, you will most likely not be able to take other ED medications as well. This is because most of them have similar mechanisms of action.

Some drugs that may interact with Mvix are:

Nitrates

These include medications used in the treatment of angina and coronary artery disease. Mvix could enhance the blood pressure-lowering ability of these drugs, which can be life-threatening if not promptly treated.

Guanylate Cyclase (GC) Stimulators

These include medications for treating pulmonary hypertension. Mvix could interact with these drugs and cause a severe drop in blood pressure.

Anti-Hypertensive Medications

Mvix may interact with these medications and enhance their blood pressure-lowering properties. These medications include drugs such as alpha-blockers, angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers, and angiotensin II receptor blockers.

CYP3A4 Inhibitors

Mvix, like other PDE5 inhibitors, gets metabolized by the enzyme CYP3A4. So, CYP3A4 inhibitor drugs may cause Mvix to last longer in the body and cause more side effects. These medications include ritonavir, ketoconazole, itraconazole, erythromycin, and others.

Alcohol

Some research shows that consuming small quantities of alcohol does not seem to affect the uptake of Mvix in the body [1]. However, there is a possibility that Mvix could enhance the side effects of alcohol in the body if taken in excess.

This is similar to the effects of most other PDE5 inhibitors when consumed with a high amount of alcohol. It could cause side effects like nasal congestion, headaches, nausea, etc., so it’s best to not take them together.

Antacids

These include medications such as Alternagel, Amphojel, Alka-Seltzer, Tums, Magnesium hydroxide, Gaviscon, Gelusil, Maalox, Mylanta, and Rolaids. These could cause a delay in the metabolism and excretion of Mvix.

CYP3A4 Inducers

These medications act opposite to CYP3A4 inhibitors and include medications such as rifampicin, carbamazepine, phenytoin, and phenobarbital. CYP3A4 inducers can increase the speed of metabolism of Mvix, which can decrease the potency of Mvix.

Who Should Avoid Using Mvix?

Mvix should be avoided by patients with:

A history of Mvix hypersensitivity
A history of NAION or “crowded” optic disc
A history of priapism
Blood disorders (hemophilia, leukemia, sickle-cell anemia)
Retinitis pigmentosa
Severe heart disease or heart valve failure
Severe kidney disease

How Does Mvix Work?

Mirodenafil, the chief ingredient in Mvix, is a phosphodiesterase5 (PDE5) inhibitor. Phosphodiesterase is an enzyme present all over the body but concentrated in the penis, corpora cavernosa, vascular smooth muscles, and platelets.

During sexual intercourse, nerve signals are sent into the pelvic region after receiving mental and sensory stimulation. This action causes the release of nitric oxide (NO) from the nerve terminals and endothelial cells within the blood vessels. Once the NO gets released, it causes a release of cyclic guanosine monophosphate (cGMP).

The release of cGMP leads to the relaxation of the muscles in the corpora cavernosa of the penis and dilation of the penile blood vessels causing a rapid entry of blood. This fast flow of the blood in the vessels causes the penis to enlarge, resulting in an erection.

After erection occurs, tunica albuginea, the membrane around the corpora cavernosa, keeps that erection intact by trapping the blood. The erection will go down only when the penis contracts following ejaculation during intercourse.

PDE 5 prevents the blood vessels in the penis and corpora cavernosa from relaxing. Besides this, most ED patients also suffer from conditions that cause problems with penile blood vessels. Some blood vessels may have a narrow lumen or have stricture and obstructions. This usually happens in old age and some diseases.

Mvix can inhibit the effect of PDE5 in the penis. It allows blood to flow properly into the penis, causing an erection. It is also able to sustain that erection until the end of the sexual intercourse.

The one catch of Mvix is that it needs sexual stimulation to work. Until and unless the person is sexually stimulated, it cannot work on its own.

Medical Research Involving Mvix

Mvix, or rather its base ingredient mirodenafil, has some research dedicated to its use and benefits [2]. Several randomized controlled trials have been conducted to see its potential.

One such study was conducted in 2008. In this study, 223 subjects were given mirodenafil for 12 weeks [3]. All participants showed significant improvement in ED symptoms.

Other Alternatives to Mvix

Many other medications can treat ED. Some may have active ingredients different from Mvix, but the mechanism of action may be similar in most of them. It may be good for you to look around and see before you decide on the best medication for you.

Here are some of the pharmaceutical alternatives for Mvix:

Avanafil (Avaforce, Stendra, Avana)
Sildenafil (Viagra, Cenforce, Kamagra, Fildena, P-Force, Vygex, etc.)
Tadalafil (Cialis, Adcirca, Vidalista, Tadacip, Forzest, etc)
Udenafil (Zydena)
Vardenafil (Levitra, Staxyn, Vilitra, Zhewitra, Savitra, & more)

Natural Alternatives to Mvix

Some natural herbs and nutrients may also help treat ED. Most of these are traditional medications and do not have much research done on their potential.

However, if you are hesitant to try pharmaceutical medications for ED, these may be a good place to start. If they do not work for you, you can always return to the standard pharmaceutical treatments.

Here are some herbs and nutrients that may help with ED:

Horny goat weed (Epimedium spp.) — This can help increase libido and may also treat ED [4].

Ginseng (Panax ginseng) — Ginseng has antioxidant properties. It can increase libido, raise stamina, and may relieve symptoms of ED [5].

Muira puama (Ptychopetalum olacoides) — can increase blood flow to the penis and help treat ED [6].

L-Arginine — can help improve ED symptoms [7].

Where to Buy Mvix?

To buy Mvix, you must first get a prescription from your doctor, as this is a prescription-only drug. After you have the prescription, you can get Mvix from your nearest pharmacy or online. The latter option may be a better choice as it is discrete and easier.

If you’re looking for a medication that can help treat your erectile dysfunction, give Mvix a try.

References Cited

Kim, B. H., Yi, S., Kim, J., Lim, K. S., Kim, K. P., Lee, B., … & Yu, K. S. (2009). Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea. Clinical therapeutics, 31(6), 1234-1243.
Park, H. J., Moon, K. H., Lee, S. W., Lee, W. K., Kam, S. C., Lee, J. H., & Park, N. C. (2014). Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. The World Journal of men’s health, 32(1), 18-27.
Paick, J. S., Ahn, T. Y., Choi, H. K., Chung, W. S., Kim, J. J., Kim, S. C., … & Jung, H. G. (2008). ED PHARMACOTHERAPY: Efficacy and Safety of Mirodenafil, A New Oral Phosphodiesterase Type 5 Inhibitor, for Treatment of Erectile Dysfunction. The journal of sexual medicine, 5(11), 2672-2680.
Shindel, A. W., Xin, Z. C., Lin, G., Fandel, T. M., Huang, Y. C., Banie, L., … & Lue, T. F. (2010). Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. The journal of sexual medicine, 7(4), 1518-1528.
De Andrade, E., De Mesquita, A. A., de Almeida Claro, J., De Andrade, P. M., Ortiz, V., Paranhos, M., … & Erdogrun, T. (2007). Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian journal of andrology, 9(2), 241-244.
Ferrini, M. G., Garcia, E., Abraham, A., Artaza, J. N., Nguyen, S., & Rajfer, J. (2018). Effect of ginger, Paullinia cupana, Muira puama, and l-citrulline, singly or in combination, on modulation of the inducible nitric oxide-NO-cGMP pathway in rats’ penile smooth muscle cells. nitric oxide, 76, 81-86.
Moody, J. A., Vernet, D., Laidlaw, S., Rajfer, J., & Gonzalez-Cadavid, N. F. (1997). Effects of long-term oral administration of L-arginine on the rat erectile response. The journal of urology, 158(3), 942-947.