Erectile dysfunction is a condition when a male partner cannot have or maintain an erection long enough to satisfy sexual intercourse. The condition worsens with age but is very common and can affect mental health.

Sometimes the maximum effective dose of usual drugs is ineffective in treating erectile dysfunction. In such cases, Sildalis, a combination drug of sildenafil and tadalafil, is more effective.

This article will guide you through each component of Sildalis, along with the benefits, cost, dose, and adverse effects.

What Is Sildalis?

Sildalis is a combination of sildenafil citrate and tadalafil. It is used to treat severe cases of erectile dysfunction and has a longer duration than many other ED medications.

What’s the Dose of Sildalis?

The available dose of Sildalis is 120 mg: 100 mg of sildenafil and 20 mg of tadalafil. Take the drug as prescribed by your doctor. The medicine is taken on an on-demand basis, but don’t take more than one pill a day.

How Long Does It Take for Sildalis to Kick In?

Tadalafil has a milder action and starts to work in 30 minutes. Sildenafil kicks in 60-70 minutes later, giving a harder erection. They work together at their best around 4 to 5 hours after taking the pill when the erection is at its maximum.

It’s best to take Sildalis 30 to 40 minutes before sexual activity.

You might experience severe dizziness, fainting, and painful or prolonged erection if you intentionally or accidentally consume more than the prescribed amount of Sildalis,. In such situations, seek medical help immediately.

How Long Does Sildalis Last?

Tadalafil lasts for around 36 hours — a big advantage over sildenafil, which only lasts for around 4 to 6 hours.

Sildalis, which is a combination of both, lasts for around 15 to 20 hours on average, and its effect could last up to 36 hours.

Only take one pill in 36 hours.

How Much Does Sildalis Cost?

The cost of the medicine usually varies depending on where you buy it from and the number of pills in the pack. If you buy a 10-pack, it will cost around $4 per pill; if you buy a pack of 100 pills, it will cost approximately $1.25 per pill.

Sildalis costs between $1.25 and $4 per pill, with the average price being $2.

The History of Sildalis

Sildenafil citrate’s effectiveness for ED was discovered accidentally during research on using it for high blood pressure. Pfizer patented the drug in 1996, and two years later, the FDA approved it. Pfizer marketed the drug under the brand name Viagra. The patent expired in 2019, making it available to other companies.

Two years after the approval of sildenafil citrate, Lilly ICOS, LLC applied for another drug — tadalafil — to treat erectile dysfunction. The major differentiation from sildenafil was its prolonged action.

In 2003, the FDA approved tadalafil for the treatment of erectile dysfunction. In 2011, the FDA approved it for signs and symptoms of benign prostatic hyperplasia (BPH). The FDA has also approved tadalafil for treating both BPH and ED where the two conditions co-exist. Tadalafil is no longer protected under patent, so the generic form is available under various brand names.

Who Should Take Sildalis?

Sildalist is beneficial for treating severe erectile dysfunction when other medicines have not worked.

The combination treatment provides a substantially stronger effect, causing a better erection. The addition of tadalafil also prolongs sildenafil’s effects. The two treat ED more effectively, which can improve mental health and relationships.

A study compared the efficacy and safety of tadalafil compared to tadalafil and sildenafil. The results show that the combination is more effective without a substantial increase in side effects [1].

Sexual arousal is still required to get an erection — Sildalis does not work as a sexual stimulant. Try implementing other things like regular exercise, eating a healthy diet, drinking plenty of fluids, reducing stress, avoiding alcohol and smoking, and engaging in foreplay before sexual activity.

Is Sildalis Safe?

Although the medicine is generally safe, there is an increased risk of side effects compared to individual medicines.

Following are a few of the side effects associated with Sidalis:

  • Abdominal pain, nausea, and vomiting
  • Abnormal sensation in the hands or feet.
  • Back and muscle pain
  • Diarrhea
  • Difficulty falling asleep or staying asleep
  • Excessive sweating
  • Fainting, dizziness, lightheadedness
  • Flushing (feeling of warmth) and blushing
  • Headache
  • Hearing problems like tinnitus
  • Heartburn
  • Muscle twitches and cramps
  • Nosebleeds
  • Pain over arms and legs
  • Palpitations, heart attacks, chest pain, and strokes.
  • Prolonged and painful erections, bleeding from the tip of the penis
  • Shortness of breath
  • Sore throat, stuffy nose
  • Vision problems like difficulty differentiating blue and green colors, light sensitivity, loss of visual field, loss of vision in one or both eyes, blurred vision, double vision, and swollen eyes

Sildalis Drug Interactions

Before taking Sildalis, talk with your doctor or pharmacist. Tell them about any substances you use, including prescriptions, over-the-counter medicines, and other drugs. Also, tell them about any vitamins, herbs, or supplements you use. Sharing this information can help you avoid potential interactions.

Some common drugs that may interact with Sildalis include:


Don’t take Sildalis if you’re taking nitrates, a type of drug used for chest pain. Taking the two can cause a serious decrease in blood pressure [2].


Sildalis and alpha-blockers are both vasodilators that can cause blood pressure to drop below healthy levels. Taking both drugs must be done carefully under the supervision of a trained medical professional.


Likewise, due to the blood pressure-lowering effects of both medicines, blood pressure may become low, leading to dizziness and feeling faint.


Some of the effects of Sildalis and alcohol are the same, which makes the effects of both drugs stronger. Low blood pressure, dizziness, headaches, and an increased heart rate are all common side effects of mixing them.


If you’re taking Sildalis and using antacids to treat heartburn, the antacids may decrease the level of Sildalis that your body absorbs. This means that you may not get the full dose of Sildalis, and it might not work as well to treat your ED or symptoms of BPH.

CYP3A4 Inhibitors

Sildalis is primarily metabolized in the liver by the CYP3A4 enzymes. Taking other drugs that are broken down by this enzyme can change how fast Sildalis breaks down, causing its half-life to be longer and increasing its levels in the body. This can increase the risk of developing side effects.

CYP3A4 Inducers

Some medications, in contrast to CYP3A4 inhibitors, increase the activity of this enzyme, causing Sidalis to be metabolized faster and its effects to be shortened or reduced.

Common CYP3A4 inducers include:

  • Carbamazepine
  • Griseofulvin
  • Phenobarbital
  • Phenytoin
  • Rifampin

Who Should Avoid Using Sildalis?

Some people should avoid using Sildalis altogether, including those with:

  • A blood disorder (hemophilia, leukemia, sickle-cell anemia)
  • A history of non-arteritic anterior ischemic optic neuropathy (NAION)
  • A history of priapism
  • Retinitis pigmentosa
  • Severe heart disease or heart valve failure
  • Severe kidney disease
  • Sildenafil hypersensitivity
  • Taking nitrates

How Does Sildalis Work?

Sildenafil and tadalafil, the ingredients of Sildalis, are phosphodiesterase-5 (PDE-5) inhibitors. Phosphodiesterase 5 is the enzyme responsible for breaking down cyclic guanosine monophosphate (cGMP) — a compound that’s produced when you are sexually stimulated, causing the smooth muscles of the cavernous bodies of the penis to relax. This muscle relaxation increases blood flow to the penile blood vessels, resulting in an erection [3].

Tadalafil is metabolized and removed slowly and therefore lasts longer than sildenafil. These two medications work synergistically, helping you get an erection faster, stronger, and for a longer period, improving your overall sexual function, and enhancing your experience.

Is Sildalis Helpful for Women?

In theory, Sildalis can improve blood flow to the clitoris and potentially improve satisfaction. However, Sildaslis isn’t recommended for women since it comes with more risks, and the benefits are inconclusive [4].

Alternatives to Sildalis

Sildalis is just one of several brand-name PDE5 inhibitors used for treating erectile dysfunction.

Some pharmaceutical alternatives for Sildalis include:

  • Avanafil (Stendra)
  • Mirodenafil (Mvix)
  • Sildenafil only medicine (Viagra)
  • Tadalafil only (Cialis)
  • Vardenafil (Levitra, Staxyn, and Vivanza)
  • Udenafil (Zydena)

Natural Alternatives To Sildalis

While there are natural alternative treatments for erectile dysfunction, nothing in the natural world is as reliable as Sildalis or other prescription medications.

Many of these natural substances lack clinical testing to definitively say they work, but people have used them for a long time for ED and other sexual problems like low libido.

These are generally safe and worth trying out before jumping into a prescription drug, but always talk to your doctor first because some interact with certain medications or have side effects.

Here are a few promising candidates worth mentioning:

Horny Goat Weed (Epimedium spp.): This plant contains a compound called icariin, which is a relatively strong PDE5 inhibitor similar to Sildalis.

L-Arginine: This amino acid is one of the required precursors for nitric oxide production, which in turn promotes the activity of cGMP to promote an erection.

Korean Red Ginseng (Panax quinquefolium): KRG extracts have been shown to improve nitric oxide production, promote dilation of the arteries in the penis, and promote erection.

Where to Buy Sildalis?

Sildalis helps solve a complex sexual problem in men. Having said that, we should not forget that combining two drugs also increases the chances of side effects. A doctor must prescribe this drug, but then you can buy it from a pharmacy or online drugstore.

Sildalis is prescribed as a part of the management plan until the cause of the sexual problem is completely resolved.

You also should note that you must provide information to your healthcare provider about your past medical history and the medications or supplements that you are taking.


  1. Cui, H., Liu, B., Song, Z., Fang, J., Deng, Y., Zhang, S., … & Wang, Z. (2015). Efficacy and safety of long‐term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia, 47(1), 20-24.
  2. Kloner, R. A., Hutter, A. M., Emmick, J. T., Mitchell, M. I., Denne, J., & Jackson, G. (2003). Time course of the interaction between tadalafil and nitrates. Journal of the American College of Cardiology, 42(10).
  3. Silvestro, S., & Allegretti, G. Viagra (sildenafil): uses, side effects, interactions, and more.
  4. Monte, G. L., Graziano, A., Piva, I., & Marci, R. (2014). Women taking the “blue pill”(sildenafil citrate): such a big deal?. Drug Design, Development and Therapy, 8, 2251.






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