Super Avana

Super Avana is a medication containing two drugs, avanafil and dapoxetine. It is used to treat erectile dysfunction (ED) and premature ejaculation (PE).

There are a few things that you should know before using this drug, such as what it is, how it works, and how it can help you. This article covers all of these points, and more.

What is Super Avana?

Super Avana is a medication containing two drugs: 100 mg of avanafil and 60 mg of dapoxetine. It is used to treat erectile dysfunction (ED) and premature ejaculation (PE).

Erectile dysfunction is a condition in which men are unable to get or maintain an erection, whereas premature ejaculation is a condition where ejaculation occurs just before or immediately after penetration. In some cases, ED may cause PE or vice versa because the inability to maintain an erection may cause a faster ejaculation.

Super Avana can treat these conditions by allowing the erection to last longer and preventing premature ejaculation. These actions are achieved by the phosphodiesterase 5 (PDE5) inhibitor avanafil and the selective serotonin reuptake inhibitor (SSRI) dapoxetine.

Super Avana is manufactured by Sunrise Remedies, a large pharmaceutical company based in India.

What’s the Dose Of Super Avana

Super Avana is available in a dosage of 160 mg with 100 mg of avanafil and 60 mg of dapoxetine. It comes in a package of 4 pills per pack.

You should take Super Avana about an hour before you have sex. The maximum dose is one pill per day. It is a prescription-only drug, and it should be taken only when needed. There is no need for daily consumption.

How Long Does it Take Super Avana To Kick In?

It takes about 15 minutes to one hour for Super Avana to work. The onset and performance levels may vary from person to person.

How Long Does Super Avana Last?

Super Avana lasts for about 3 to 4 hours. This is enough time for the sexual intercourse to take place.

How Much Does Super Avana Cost?

Super Avana costs from $6.00 to $9.99 per tablet, which is significantly cheaper than other ED medications.

The History of Super Avana

Each drug of Super Avana has its history. Avanafil was invented at Mitsubishi Tanabe Pharma, also known as Tanabe Seiyaku. It was licensed to Vivus Inc., which partnered with Menarini group to produce and sell avanafil with the brand name Spedra in over 40 countries. It was approved for use in erectile dysfunction by the FDA on April 27, 2012, and by the EMA on June 21, 2013.

The second drug of Super Avana, dapoxetine, was first used to treat depression. Later on, it was found that it can treat premature ejaculation. It was first made by Eli Lilly pharmaceutical company.

After this, dapoxetine was bought by Johnson and Johnson in 2003, but its use was discontinued in the US in 2017. It has approval for use in most other countries.

Combining these two medications can be an effective treatment for ED and premature ejaculation. Hence, Sunrise Pharmaceuticals started producing this combination drug to treat ED and PE.

Who Should Take Super Avana?

Super Avana is for men who cannot maintain an erection long enough for sexual intercourse and for men who have a condition where they ejaculate prematurely.

It is a prescription-only drug, so you need to first get examined by your doctor to confirm your diagnosis, and only then you may get prescribed this medication.

Is Super Avana Safe?

Super Avana is generally well-tolerated by most men.

Common Side Effects of Super Avana

Super Avana may cause some side effects, especially with improper dosing.

Some side effects that may occur while using Super Avana are:

Cough
Diarrhea
Dry mouth
Excessive sweating
Flushing
Headache
Insomnia
Light-headedness
Muscle aches
Nausea
Pain in extremities
Priapism
Stomach upset
Stuffy or runny nose
Upper respiratory tract infections

Potential Drug Interactions With Super Avana

Some medications can interact with Super Avana and cause mild to potentially dangerous adverse effects.

The drugs that can interact with Super Avana include:

Nitrates

Nitrates are commonly used in angina and coronary heart diseases. Super Avana can interact with nitrates and rapidly lower blood pressure, so it is best to avoid taking them together.

Guanylate Cyclase (GC) Stimulators

GC stimulators are mostly used to treat pulmonary hypertension. They can interact with Super Avana and rapidly decrease blood pressure.

Antihypertensive Medications

These include medications such as alpha-blockers, angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers, and angiotensin II receptor blockers. Super Avana can exacerbate their blood pressure-lowering abilities.

CYP3A4 Inhibitors

Super Avana is metabolized by the CYP3A4 enzymes. Medications that inhibit this enzyme can slow down the metabolism of Super Avana, increasing the duration of its effect.

Alcohol

Super Avana can worsen the side effects of any kind of alcohol. It can cause side effects such as headaches, nausea, vomiting, etc. So, alcohol should not be taken with Super Avana.

Antacids

These include drugs such as Alternagel, Amphojel, Alka-Seltzer, Tums, Magnesium hydroxide, Gaviscon, Gelusil, Maalox, Mylanta, and Rolaids. These can lower the uptake of Super Avana in the body, which lowers its efficacy.

CYP3A4 Inducers

These include medications like rifampicin, carbamazepine, phenytoin, and phenobarbital. They can increase the action of the CYP3A4 enzyme and result in faster metabolism and elimination of Super Avana from the body. This lowers its duration of action and efficacy.

MAOI Inhibitors

Dapoxetine in Super Avana can interact with MAOI inhibitors. This interaction can cause side effects such as hyperthermia, myoclonus, mental status changes, rigidity, and autonomic instability.

Who Should Avoid Using Super Avana

Super Avana should be avoided by patients with:

A history of priapism
A history of syncope
Blood disorders (hemophilia, leukemia, sickle-cell anemia)
Liver disease
Low blood pressure
Mania or severe depression
Severe heart disease
Severe kidney disease

How Does Super Avana Work?

The two ingredients of Super Avana, avanafil and dapoxetine, work in their own unique way.

Avanafil is a phosphodiesterase 5 (PDE5) inhibitor. PDE5 is present in different parts of the body but is concentrated mainly in corpora cavernosa, platelets, skeletal muscles, and vascular and visceral muscles.

Normally, during sexual intercourse, nerve stimulation in the pelvic region leads to nitric oxide (NO) release. Then, NO causes an increase in the levels of cyclic guanosine phosphate (cGMP).

cGMP causes relaxation of the penile smooth muscles and corpora cavernosa. It also increases blood flow to the penis, leading to an erection.

In ED, PDE5 inhibits cGMP’s actions, which may be the cause of improper functioning of the penis. ED may also occur due to issues with penile blood vessels.

Avanafil in Super Avana inhibits PDE5, thereby allowing a proper erection. It has a faster onset of action and can work as fast as 15 minutes.

The second drug in Super Avana, dapoxetine, is a selective serotonin reuptake inhibitor (SSRI). It slows down the ejaculatory expulsion reflex and stops the neuronal reuptake of serotonin.

Premature ejaculation can be caused by a decrease in serotonin levels. Dapoxetine can increase the level of serotonin in the nerve and improve control over ejaculation [2]. This slows down the speed of ejaculation, resulting in a longer-lasting erection.

Thus, avanafil of Super Avana acts on erectile dysfunction, while dapoxetine prevents premature ejaculation. Using them together helps an erection to occur first and then last for a longer time. These actions ensure that the erection lasts long enough for intercourse without premature ejaculation.

The combined form of these two drugs is stronger than using just one. It may be helpful in patients who do not respond to other ED medications.

Medical Research Involving Super Avana

Research on the effectiveness of combined avanafil and dapoxetine is lacking. However, the individual drugs themselves have been researched extensively.

Avanafil has been well-established as a drug for erectile dysfunction [3]. Some research has shown dapoxetine to be effective in treating PE [4].

Other Alternatives to Super Avana

There are other alternatives to Super Avana. Some of them may use the same active ingredient, while others use ingredients with a similar mechanism of action.

Pharmaceutical Alternatives

Avanafil (Avaforce, Stendra, Avana)
Mirodenafil (Mvix)
Sildenafil (Viagra, Cenforce, Kamagra, Fildena, P-Force, Vygex, & more)
Sildenafil and dapoxetine combination (Suhagra force, Da Sutra, Dapsil-D
SSRIs (escitalopram like Lexapro, sertraline like Zoloft, paroxetine like Paxil, fluoxetine like Prozac)
Tadalafil (Cialis, Adcirca, Vidalista, Tadacip, Forzest, & more)
Tadalafil and dapoxetine combination (Uphold, TD pill, Dejac-T, ED Save Plus, Duraplus, Edon-D
Udenafil (Zydena)
Vardenafil (Levitra, Staxyn, Vilitra, Zhewitra, Savitra, & more)

Natural Alternatives

Many herbs and nutrients have long been used to treat erectile dysfunction. However, they do not have enough evidence to support their efficacy.

For those hesitant to start prescription medications, these can be tried.

Some natural herbs alternatives that may help with ED and PE [5, 6, 7, 8, 9]:

Catuaba (Trichilia catigua or Erythroxylum Catuaba)
Horny Goat Weed (Epimedium spp.)
Korean Red Ginseng (Panax quinquefolium)
L-Arginine
Zinc

Where to Buy Super Avana

Super Avana is a prescription-only drug in most countries, but not in the United States. Once you get the prescription for it, you can buy it from the nearest pharmacy or online. The latter may be a better alternative as it is discreet and easier.

References Cited

Clément, P., Bernabé, J., Gengo, P., Denys, PShindel, A. W., Xin, Z. C., Lin, G., Fandel, T. M., Huang, Y. C., Banie, L., … & Lue, T. F. (2010). Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. The journal of sexual medicine, 7(4), 1518-1528.
., Laurin, M., Alexandre, L., & Giuliano, F. (2007). Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine. European urology, 51(3), 825-832.
Kendirci, M., Salem, E., & Hellstrom, W. J. (2007). Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Therapeutics and clinical risk management, 3(2), 277
Belkoff, L. H., McCullough, A., Goldstein, I., Jones, L., Bowden, C. H., DiDonato, K., … & Day, W. W. (2013). An open‐label, long‐term evaluation of the safety, efficacy, and tolerability of avanafil in male patients with mild to severe erectile dysfunction. International journal of clinical practice, 67(4), 333-341.
McMahon, C. G. (2011). Efficacy of dapoxetine in the treatment of premature ejaculation. Clinical Medicine Insights: Reproductive Health, 5, CMRH-S7337.
Lim, P. H. (2017). Asian herbals and aphrodisiacs used for managing ED. Translational andrology and urology, 6(2), 167.
Dissanayake, D. M. A. B., Wijesinghe, P. S., Ratnasooriya, W. D., & Wimalasena, S. (2009). Effects of zinc supplementation on the sexual behavior of male rats. Journal of human reproductive sciences, 2(2), 57.
Moody, J. A., Vernet, D., Laidlaw, S., Rajfer, J., & Gonzalez-Cadavid, N. F. (1997). Effects of long-term oral administration of L-arginine on the rat erectile response. The journal of urology, 158(3), 942-947.
De Andrade, E., De Mesquita, A. A., de Almeida Claro, J., De Andrade, P. M., Ortiz, V., Paranhos, M., … & Erdogrun, T. (2007). Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian journal of andrology, 9(2), 241-244.