Erectile dysfunction is very common, but fortunately, there are many ways to treat it. Tadagra is one such medication and is based on the more common drug Cialis.
Before using Tadagra, there are some things you should be aware of. This includes what Tadagra is, how it is used, and its effects. We’ll talk about all these things in this article.
Let’s get right to it.
What Is Tadagra?
Tadagra is a generic form of the drug tadalafil, which belongs to a class called phosphodiesterase 5 inhibitors (PDE5). It treats erectile dysfunction (ED) and benign prostatic hyperplasia (BPH).
Cialis, another popular ED treatment medication, also uses this same basic ingredient, tadalafil. Tadagra is produced by Health Guard Private Limited, a company based in India.
Tadagra prevents the body from producing the enzyme phosphodiesterase type 5 (PDE5). In most patients with ED, this enzyme’s actions are what prevent an erection. By stopping PDE5’s actions and boosting blood flow in the penis, Tadagra can help cause an erection.
Tadagra’s prolonged period of action makes it significantly more effective than the majority of other ED medications.
What’s the Dose of Tadagra?
Tadagra is available as a 20 mg tablet. It is a small yellow teardrop-shaped tablet that comes in a 10-pack.
In most countries, Tadagra is available only by prescription, so you have to get a checkup done by your physician.
For ED, Tadagra is used only when needed. Unless prescribed otherwise, it is unnecessary to take it daily. You can take a maximum dose of one pill per day or as prescribed by your physician.
For benign prostate hyperplasia, the dosage depends on the prescription. Either way, never take more than the recommended dose. Overdosing can cause undesirable side effects, which may become fatal. Never discontinue taking the medication without first talking to your physician.
How Long Does It Take for Tadagra To Kick In?
Tadagra typically begins its actions within 30 to 90 minutes after consumption. It might occasionally take a little longer, so wait a while if you are a first-time user.
There is a prerequisite for Tadagra to function properly — it requires sexual stimulation to function. Therefore, take it around 30 minutes before sexual activity.
How Long Does Tadagra Last?
Tadagra’s effects can last for almost 36 hours as it has a half-life of nearly 17.5 hours. This is much longer than other medications used to treat ED, like Viagra and Levitra. It means Tadagra can last for a longer time in your body and helps to sport an erection for a much longer time.
How Much Does Tadagra Cost?
Tadagra costs about $0.39 per 20 mg tablet. Its price is less compared to other ED medications like Viagra.
The History of Tadagra
In 1993, tadalafil was initially developed as a potential heart medication. Its capacity to induce an erection was an accidental discovery. The company ICOS, however, recognized this as a potential therapy for ED. In 1994, ICOS applied for a patent for it.
In 2003, the FDA approved tadalafil as an ED therapy, allowing Lilly ICOS to produce and sell it. In 2017, the drug’s patent expired, opening the door for other pharmaceutical firms to manufacture it at a lower cost. As soon as this patent expired, Health Guard, India Pvt LTD started making Tadagra.
Who Should Take Tadagra?
As a prescription-only drug, Tadagra requires a prescription from a licensed physician. Men with benign prostatic hyperplasia or ED may be prescribed Tadagra by medical professionals. The medication Tadagra is also used to treat pulmonary arterial hypertension.
To determine whether your underlying medical conditions or existing drugs might interact with Tadagra, your doctor will first evaluate you. They will then prescribe this medication to you based on your requirements.
Is Tadagra Safe?
Tadagra is generally safe for use by most users. But like most medications, it has some side effects.
Common Side Effects of Tadagra include:
- Back pain
- Chest pain
- Cough
- Diarrhoea
- Flushing
- Headache
- Muscle aches
- Pain in the extremities
- Priapism
- Stomach Upset
- Stuffy or runny nose
- Upper Respiratory Tract Infections
- Vision Disturbances
Potential Drug Interactions With Tadagra
Tadagra and certain medications may interact, leading to potentially harmful adverse effects. The majority of other PDE5 inhibitors may cause the same side effects.
To prevent drug interactions, speak with your doctor beforehand.
Some common medications that may interact with Tadagra include:
Nitrates
These drugs treat cardiac conditions like coronary artery disease and angina. Tadagra may interact with these drugs and dramatically reduce blood pressure.
Amyl nitrate, nitroglycerin, isosorbide, nitroprusside, and other medications are examples of nitrates.
Alcohol
Any type of alcohol can react with Tadagra and might cause significant side effects, including headaches, vomiting, dizziness, and low blood pressure.
Guanylate Cyclase Stimulators
Combined with these medications, Tadagra can reduce blood pressure.
An example is Adempas (riociguat), which is frequently prescribed to treat pulmonary hypertension.
CYP3A4 Inhibitors
The primary ingredient of Tadagra, tadalafil, is metabolized by the enzyme CYP3A4 in the liver. Taking Tadagra along with CYP3A4 inhibitors can delay its clearance, making its effects last longer and increasing the risk of adverse effects.
Ritonavir, ketoconazole, itraconazole, and erythromycin are examples of CYP34A inhibitors.
Anti-Hypertensive Medications
Anti-hypertensives and Tadagra may interact, resulting in a sharp reduction in blood pressure.
Alpha-blockers, ACE inhibitors, calcium channel blockers, and angiotensin II receptor blockers are a few examples of such drugs.
CYP3A4 Inducers
When compared to CYP3A4 inhibitors, these drugs operate oppositely. They shorten Tadagra’s half-life by accelerating the drug’s metabolism. This means the drug leaves the system earlier than expected, leading to decreased effects.
CYP3A4 inducers include phenobarbital, phenytoin, carbamazepine, rifampin, and others.
Antacids
Antacids can decrease the body’s ability to absorb Tadagra, decreasing its effectiveness. As a result of this, Tadagra won’t last long enough in the system to do its work.
Various antacids consist of Alternagel, Amphojel, Alka-Seltzer, Tums, magnesium hydroxide, Gelusil, Maalox, Mylanta, Rolaids, etc.
Who Should Avoid Using Tadagra?
There are some conditions where it can be dangerous for men to take Tadagra.
Avoid taking Tadagra if you suffer from any of the following:
- Gastric ulcers
- Blood ailments, such as sickle cell anemia, leukemia, or hemophilia
- Severe heart condition or heart valve issues
- Allergic or hypersensitive to tadalafil
- Suffering from severe kidney illness
- “Crowded” or NAION optic disc
- History of priapism
- History of retinitis pigmentosa
Women and children should not take Tadagra.
How Does Tadagra Work?
Tadagra works as a phosphodiesterase 5 (PDE5) inhibitor. It functions by enhancing blood flow in the arteries supplying the corpora cavernosa, a part of the penis. The penis, corpora cavernosa, platelets, skeletal muscles, and vascular and visceral muscles are the most common locations where PDE5 is found.
Under normal circumstances, the pelvic area’s nerves activate following sexual arousal. Nitric Oxide (NO) starts to circulate in and around the arteries surrounding the smooth muscles of corpora cavernosa. Cyclic guanosine monophosphate (cGMP) is a chemical that is increased by nitric oxide. It causes the corpora cavernosa and penile smooth muscles to relax, as well as an increase in blood flow to the penis. The actions of the cGMP allow the penis to become erect.
In the majority of ED patients, these arteries are damaged and dysfunctional. PDE5 prevents cGMP from working as it should, preventing the smooth muscles of the penis from relaxing. As a result, there is improper blood flow into the penis and no erection.
Tadagra combats this by preventing the PDE5 enzyme from functioning and relaxes the blood vessels, permitting normal blood flow into them. Additionally, it aids in keeping the erection for as long as necessary for sex.
Tadagra can’t accomplish all of this on its own, though. You must be sufficiently sexually charged for it to function.
Medical Research Involving Tadagra
Research shows that tadalafil, the generic version of Tadagra, is effective in treating ED and BPH [1, 9].
There hasn’t been much research on Tadagra, though, simply because companies use the same formulas to make the medications. Once the patent on the generic drug expires, other companies can begin mass-producing the identical drug.
Best Alternatives of Tadagra
ED can be treated with several different drugs. They might contain the same active ingredient as Tadagra or various ingredients that function similarly to it.
Pharmaceutical Alternatives of Tadagra
Tadagra has a lot of additional options available. Some of these might cost less, while others might cost more. Nevertheless, they all work similarly.
These other name-brand medications have similar effects to Tadagra:
- Avanafil (Avaforce, Stendra, Avana)
- Mirodenafil (Mvix)
- Sildenafil (Viagra, Cenforce, Kamagra, Fildena, P-Force, Vygex, & more)
- Tadalafil (Cialis, Adcirca, Vidalista, Tadacip, Forzest, & more)
- Udenafil (Zydena)
- Vardenafil (Levitra, Staxyn, Vilitra, Zhewitra, Savitra, & more)
Natural Alternatives
Tadagra has various natural substitutes available as well — herbs and several nutrients are among them. However, the majority of them lack enough clinical testing and sufficient research to demonstrate their efficacy.
If you are afraid to attempt prescription medications first, these complementary and alternative treatments might be a good starting point. You can advance to pharmaceutical drugs if they don’t work.
A few alternative herbs and supplements for the treatment of ED are listed below:
Horny goat weed (Epimedium spp.) — This plant has an enzyme called icariin, which is similar to Tadagra in its ability to inhibit PDE5. Joint aches, erectile dysfunction, and poor libido can be treated with horny goat weed [2].
Ginseng (Panax ginseng) — Ginseng is a herb that has been suggested to be effective in treating ED as well as several other conditions such as headache, agitation, and upset stomach [3].
Muira puama (Ptychopetalum olacoides) — This herb improves sexual arousal and treats ED [4]. It also improves stamina and helps in better sexual performance.
L-arginine — This amino acid produces nitric oxide, which then assists in the production of cGMP, assisting in ED [5]. This allows for greater blood circulation to the penis, making an erection last for a longer time. It may also help provide more energy and assist in bodybuilding.
Catuaba (Trichilia catigua or Erythroxylum Catuaba) — Catuaba can help with ED and low libido [6]. It’s often used to treat sexual weakness and may have aphrodisiac characteristics.
Yohimbe (Pausinystalia johimbe) — Yohimbe increases sexual performance and may treat ED [7]. Yohimbine blocks alpha-2 adrenergic receptors and may cause nitric oxide to release more quickly. As a result, the penis’ blood vessels may enlarge and create an erection.
Tribulus (Tribulus terrestris) — Tribulus can help treat ED, increase libido, and improve some minor ailments associated with the urinary tract, such as urinary tract infections [8].
Where to Buy Tadagra
To use Tadagra, you must first get a prescription from your physician since it is a prescription-only medication. After receiving it, you can purchase it online or from any nearby pharmacy. It is better to buy them online because it is more covert and eliminates the headaches of shopping out.
Remember, there are natural alternatives worth trying, along with less expensive generic medications for erectile dysfunction treatment.
Tadagra might be the best option for you as a long-lasting treatment for benign prostatic hyperplasia and erectile dysfunction, but your doctor can help you decide.
References
- Costa, P., Grivel, T. and Gehchan Naji, 2009. Tadalafil once daily in the management of erectile dysfunction: patient and partner perspectives. Patient Preference and Adherence, p.105.
- Liu, W. J., Xin, Z. C., Xin, H., Yuan, Y. M., Tian, L., & Guo, Y. L. (2005). Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian journal of andrology, 7(4), 381-388.
- E. D. Andrade, A. A. D. Mesquita, J. D. A. Claro, P. M. D. Andrade, V. Ortiz, M. Paranhos, M. Srougi, and T. Erdogrun, “Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction,” Asian Journal of Andrology, vol. 9, no. 2, pp. 241–244, 2007.
- M. G. Ferrini, E. Garcia, A. Abraham, J. N. Artaza, S. Nguyen, and J. Rajfer, “Effect of ginger, Paullinia cupana, Muira puama, and l – citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells,” Nitric Oxide, vol. 76, pp. 81–86, 2018.
- Melman, A. (1997). L-Arginine and penile erection. The Journal of urology, 158(3), 686-686.
- P. H. C. Lim, “Asian herbals and aphrodisiacs used for managing ED,” Translational Andrology and Urology, vol. 6, no. 2, pp. 167–175, 2017.
- M. P. Carey and B. T. Johnson, “Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations,” Archives of Sexual Behavior, vol. 25, no. 4, pp. 341–360, 1996.
- H. Zhang, W.-T. Tong, C.-R. Zhang, J.-L. Li, H. Meng, H.-G. Yang, and M. Chen, “Gross saponin of Tribulus terrestris improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum,” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. Volume 12, pp. 1705–1716, 2019.
- Mónica, F. Z., & De Nucci, G. (2019). Tadalafil for the treatment of benign prostatic hyperplasia. Expert opinion on pharmacotherapy, 20(8), 929-937.
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