V Tada Super

V–Tada Super is an orally administered drug proven to be effective in treating erectile dysfunction and symptoms of benign prostatic hyperplasia in males [1].

It is also used to treat high blood pressure in the arteries that supply blood to the lungs, known as pulmonary artery hypertension.

Read on ahead to know more about the uses, mechanism of action, potential side effects, and dosage of V-Tada Super.

What Is V–Tada Super?

V-Tada Super is a medicine used in erectile dysfunction manufactured by Vipro Life Science Pharmaceuticals. The active ingredient in V–Tada Super, namely tadalafil, is widely known by its trade name Cialis.

The first data report on the efficacy and duration of tadalafil was demonstrated by Brock and colleagues at the 97th annual meeting of the American Urological Association (AUA) in Orlando, Florida, in 2002.

A year later, Brock’s data analysis of five randomized clinical trials was published, and the drug successfully received approval from the Food and Drug Administration (FDA) for use in the United States on November 21, 2003 [2].

What’s the Dose Of V–Tada Super?

V–Tada Super is available in four different doses, as follows:

2.5 mg
5 mg
10 mg
20 mg

The FDA approved tadalafil 5 mg, 10 mg, and 20 mg as a treatment for patients with erectile dysfunction in November 2003. The recommended daily dose for use as required is 10 mg but is increased to 20 mg or lowered to 5 mg based on individual response and ability to tolerate the drug.

How Long Does It Take For V–Tada Super To Kick In?

The drug should be taken 30 to 60 minutes before sexual activity. However, the drug only works if sexual arousal is also present [3].

How Long Does V–Tada Super Last?

The duration of efficacy is approximately 36 hours because it has a half-life of 17.5 hours, unlike sildenafil and vardenafil, which have a half-life of 4 hours [3].

How Much Does V–Tada Super Cost?

The cost is comparable to drugs like sildenafil or vardenafil.

A box of 30 tablets to 240 tablets costs $29 to $175. Because of its longer duration of action, fewer doses may be needed.

Who Should Take V–Tada Super?

Tadalafil is approved for treating patients with erectile dysfunction [2]. While tadalafil is well known as a treatment for ED, it is even safe and effective in benign prostate hypertrophy patients [4].

It is also used in patients with high blood pressure in blood vessels of the lungs, known as pulmonary artery hypertension (PAH). It is off-label and used as a prophylaxis for lung congestion due to fluid accumulation (pulmonary edema), also known as high altitude sickness [5]. Another off-label use is in sexual dysfunction in patients taking antidepressants.

Is V–Tada Super Safe?

Yes, it is well-tolerated and effective in patients with erectile dysfunction. Most of the experimental trials report side effects are dose-dependent and due to blood vessel dilation from PDE-5 enzyme inhibition.

In 11 randomized, double-blinded, placebo-controlled trials on tadalafil in 2102, men with mild-to-severe erectile dysfunction of various causes found it was effective for 36 hours, irrespective of disease severity and cause [6].

Common Side Effects Of V–Tada Super

Some side effects that may be seen with V-Tada Super include:

Back pain
Dyspepsia
Flushing
Headaches
Myalgia
Nasal congestion
Nasopharyngitis
Pain in limbs

Potential Drug Interactions With V–Tada Super

The following substances can interact with V-Tada Super, so make sure your doctor knows about any other medications you’re using.

Nitrates

Nitrates such as isosorbide mononitrate, dinitrate, and nitroglycerin are most commonly prescribed to patients diagnosed with angina and coronary artery disease. Because of its longer half-life, nitrate medications must be administered 48 hours after taking tadalafil, compared to 24 hours for sildenafil and vardenafil due to the risk of hypotension.

Alpha–Blockers

Alpha–Blockers such as prazosin and doxazosin are usually prescribed in patients with hypertension with or without benign prostate hypertrophy. Alpha-blockers and tadalafil have similar actions on PDE-5 and can cause an additive blood pressure-lowering effect.

Antihypertensives

Tadalafil can lower blood pressure when taken with antihypertensives such as amlodipine, angiotensin II receptor blockers, enalapril, and metoprolol can cause small reductions in blood pressure if both drugs are taken simultaneously.

Guanylate Cyclase (GC) Stimulators

Tadalafil and guanylate cyclase stimulators such as Riociguat can significantly lower blood pressure.

CYP34A Inhibitors

Drugs such as ketoconazole, erythromycin, grapefruit juice, and protease inhibitors decrease the activity of CYTP450. A decrease in this enzyme activity lowers the metabolism of tadalafil, leading to an increase in its concentration and the exaggerated response of the drug.

CYP34A Inducers

Drugs such as rifampin, phenytoin, phenobarbital, and carbamazepine are promoters of CYT P450 enzymes. An increase in this enzyme’s activity speeds up V-Tada Super’s metabolization, leading to a reduced concentration and efficacy of the drug.

Alcohol

Both alcohol and tadalafil are mild vasodilators. When ingested together, the blood pressure-lowering effects of each may increase. In addition, the consumption of alcohol with tadalafil can increase the risk of orthostatic hypotension, tachycardia, dizziness, and headache.

Who Should Avoid Using V–Tada Super?

V-Tada Super is not suitable for patients with the following:

A history of NAION
A history of allergic reactions to tadalafil
A history of priapism
Blood disorders (sickle cell anemia, hemophilia, leukemia)
Low or uncontrolled high blood pressure
Multiple myeloma
Peyronie’s disease (curved penis)
Retinitis pigmentosa
Severe kidney disease
Severe liver or heart problem

How Does V–Tada Super Work?

This drug blocks phosphodiesterase type 5, a major cGMP hydrolyzing enzyme located in the vascular smooth muscle corpus cavernosum of the penis [7].

This leads to an increase in cGMP, which enhances smooth muscle relaxation and improves the blood flow to the corpus cavernosum.

This increase in blood flow causes engorgement of the corpus cavernosum leading to penile erection. However, for the drug to work properly, sexual stimulation is essential.

Medical Research Involving V–Tada Super

Research on V-Tada Super itself is limited. This is because generic medications can be made easily from the same recipe as the already established drugs on the market once the patents expire. Hence, drug manufacturers have no incentives to do any research.

Alternatives To V–Tada Super

Hundreds of ED drugs are sold in the market, some with the same or different active ingredients but with similar mechanisms of action.

Pharmaceutical Alternatives

V–Tada Super is based on a generic medication, which means several other companies manufacture similar medications. The price can vary greatly, but all have the same or similar compounds.

They are as follows:

Avanafil (Avaforce, Stendra, Avana)
Mirodenafil (Mvix)
Sildenafil (Viagra, Fildena, P-Force, Vygex)
Tadalafil (Cialis, Tadagra, Tadovas, Tadact, Tadacip, Tadalip)
Udenafil (Zydena)
Vardenafil (Levitra, Vilitra, Savitra)

Natural Alternatives

Several natural herbal medicines facilitate sexual performance. These have little evidence to back their effectiveness in treating ED, but those reluctant to try medications can start with these first.

Horny goat weed (Epimedium spp.)

Horny goat weed is a Chinese herb also known as “Yin-yang-hou.” It is believed that its active component, glycosides icariin, improves male sexual performance through vasodilatory effects. These peripheral vasodilatory effects might be due to sympathetic ganglion and calcium channel blockade.

Ginseng (Panax ginseng)

Ginseng contains the active component ginsenoside, which induces nitric oxide (NO) release from the endothelial cells and increases the sensitivity of vascular smooth muscles to NO. This release of NO enhances blood flow into the corpus cavernosum leading to penile erection [8].

L-Arginine

This is an amino acid necessary for the synthesis of NO. It promotes the relaxation of smooth muscles in the corpus cavernosum, improving blood flow and causing an erection.

Catuaba (Trichilia catigua or Erythroxylum catuaba)

This is an aphrodisiac, and increases nitric oxide levels. NO improves blood flow to the penis and thereby enhances penile erection.

Tongkat Ali (Eurycoma longifolia)

It improves erectile function by increasing testosterone and cGMP levels. It also promotes sperm production, motility, and energy levels by increasing ATP production through oxidative phosphorylation.

Where to Buy V–Tada Super?

The drug is readily available in local pharmacies in many countries and in online stores. Buying online is preferred by most as it is discrete and time-saving. However, a prescription is essential to buy the medication online as well.

References Cited

Curran, M. P. (2012). Tadalafil: in the treatment of signs and symptoms of benign prostatic hyperplasia with or without erectile dysfunction. Drugs & aging, 29(9), 771.
Coward, R. M., & Carson, C. C. (2008). Tadalafil in the treatment of erectile dysfunction. Therapeutics and clinical risk management, 4(6), 1315.
Noviasky, J. A., & Masood, A. (2004). Tadalafil (Cialis) for erectile dysfunction. American family physician, 70(2), 359.
Carson, C. C., Rosenberg, M., Kissel, J., & Wong, D. G. (2014). Tadalafil–a therapeutic option in the management of BPH‐LUTS. International journal of clinical practice, 68(1), 94-103.
Stream, J. O., & Grissom, C. K. (2008). Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment. Wilderness & environmental medicine, 19(4), 293-303.
Carson, C. C., Rajfer, J., Eardley, I., Carrier, S., Denne, J. S., Walker, D. J., … & Cordell, W. H. (2004). The efficacy and safety of tadalafil: an update. BJU international, 93(9), 1276-1281.
Frajese, G. V., Pozzi, F., & Frajese, G. (2006). Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence. Clinical interventions in aging, 1(4), 439.
Leung, K. W., & Wong, A. S. (2013). Ginseng and male reproductive function. Spermatogenesis, 3(3), e26391.