Vigora

Vigora contains sildenafil, a phosphodiesterase 5 inhibitor. It is used in the treatment of erectile dysfunction. It is a red-colored pill that increases blood flow to the penis, causing an erection long enough for sexual intercourse.

There are a few things you should be aware of when it comes to Vigora. We’ll go over them in detail in this article.

What is Vigora?

Vigora, a generic sildenafil, is produced by Zydus Lifesciences Limited and is used mainly for erectile dysfunction in men.

Erectile dysfunction is a condition in which a man cannot achieve and maintain a satisfactory erection for sexual activity. This happens because of reduced blood flow caused by physical injuries, medical diseases, or psychological problems such as anxiety, stress, and depression.

Vigora relaxes the blood vessels, allowing more blood to flow to the penis, and helps maintain an erection long enough to have sex.

What’s the Dose of Vigora?

Vigora comes in a four-pack of small, red-colored, 100 mg pills. It should be taken about half an hour before having sex. The most a person can take is once a day.

In most countries, Vigora is only available with a prescription, so you will need to be evaluated by a licensed physician before purchasing it.

How Long Does It Take Vigora to Work?

Vigora takes 30 to 60 minutes but could be a little longer in some instances. If you are a first-time user, you may need to wait a little longer.

How Long Does Vigora Last?

Vigora’s effects last for 3 to 4 hours after you’ve taken it. Incorrect doses or overloading can sometimes cause the effects to continue longer than expected.

What’s the Cost of Vigora?

Each 100 mg tablet of Vigora costs around $0.39 — less expensive than many other ED drugs.

Who Can Take Vigora?

Vigora is for men who have erectile dysfunction (ED). It is not recommended for women and children.

Is Vigora Safe?

Vigora is relatively safe for use in most men. It is not recommended for anyone with heart conditions or those who are on any long-term medications. If you have either or both of these, make sure the physician is aware before taking Vigora.

Common Side Effects of Vigora

Vigora, like most other medications, has some adverse effects — it affects the entire body rather than just one system. However, the majority of these side effects are caused by incorrect or excessive dosage.

Abnormal vision
Back pain
Blue tinted vision
Dizziness
Headaches
Hot flushes
Muscle pain
Nasal congestion
Nausea
Rash
Sensitivity to light
Stomach upset
Tingling sensation in arms and feet
Vision loss

The History of Vigora

Sildenafil, dubbed the “miracle drug,” was first manufactured in 1989. Its first application was as a possible heart medication. Its potential to generate an erection in people with ED was discovered by chance. However, it completely altered the trajectory of this disease’s treatment.

Following its discovery, Pfizer patented the medicine as Viagra in 1996. The FDA approved it in 1998.

The patent on sildenafil ended in 2019, and several pharmaceutical businesses around the world began making it at a considerably lower cost.

How Does Vigora Work?

Sildenafil is an erectile dysfunction treatment that is taken orally. It restores poor erectile function by boosting blood flow to the penis.

Sexual stimulation releases nitric oxide (NO) in the corpus cavernosum — the physiological mechanism responsible for an erection. Nitric oxide activates guanylate cyclase, producing more cyclic guanosine monophosphate (cGMP). This relaxes the smooth muscle in the corpus cavernosum and allows blood to flow freely.

PDE5 is responsible for cGMP breakdown; sildenafil is a strong and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). Sildenafil affects erections through a peripheral mechanism.

In isolated human corpus cavernosum, sildenafil has little direct relaxant effect, but it amplifies the relaxant impact of NO on this tissue. When the NO/cGMP pathway is active, as it is with sexual excitement, sildenafil inhibits PDE5, resulting in higher cGMP levels. Because of this, sexual stimulation is required for sildenafil to deliver its intended effects.

Medications That Can Interact With Vigora

Some drugs may interact with Vigora, resulting in unpleasant or dangerous side effects. If you’re taking any of these medications, let your doctor know ahead of time. If you take drugs that react with Vigora, most other ED medications will likely react similarly.

The following medications may interact with Vigora:

Nitrates

Certain heart problems are treated with nitrates, such as nitroglycerin. Angina and coronary artery disease are two examples. Nitrates help to reduce blood pressure; Vigora’s vasodilating properties can also reduce blood pressure. As a result, taking both could result in dangerously low blood pressure.

Guanylate Cyclase (GC) Stimulators

These drugs treat heart failure and pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the lungs. They function by increasing soluble guanylyl cyclase (SGC) activity, a cardiopulmonary enzyme that relaxes vascular smooth muscles. This causes pulmonary vasodilation, lower PAH, and enhanced cardiac output.

Because these medications lower blood pressure in the same way Vigora does, taking them together could result in a rapid reduction in blood pressure, leading to fainting, dizziness, and loss of consciousness.

CYP3A4 Enzyme Inhibitors

CYP3A4 enzymes are responsible for metabolizing Vigora. Any changes in the enzyme’s activity could affect how long Vigora stays in the body. Drugs that block this enzyme may cause Vigora’s metabolism and excretion to stall, increasing the likelihood of more severe side effects.

Common inhibitors include ritonavir, ketoconazole, itraconazole, and erythromycin.

Alcohol

Alcohol and Vigora should not be used together because the latter can exacerbate the negative effects of alcohol, including headaches, nausea, vomiting, and other symptoms.

Antacids

Antacids neutralize or counteract the acid in the stomach, relieving indigestion and heartburn. They can sometimes bind to medications, reducing their absorption and effects. Antacids can cause reduce Vigora’s absorption, making it less effective.

Alternagel, Amphojel, Alka-Seltzer, Tums, magnesium hydroxide, Gaviscon, Gelusil, Maalox, Mylanta, and Rolaids are among them.

CYP3A4 Inducers

In contrast to CYP3A4 inhibitors, these medicines have the opposite effect. By raising the activity of the CYP3A4 enzyme, these medications can speed up the metabolism of Vigora, making it leave the body too fast, decreasing the effects.

CYP3A4 inducers include rifampicin, carbamazepine, phenytoin, and phenobarbital.

Who Should Not Use Vigora?

Vigora is not for use in women or children. There are also certain conditions when Vigora should not be used, such as:

Hypersensitive to Vigora
History of priapism
Severe kidney disease
Certain blood disorders (hemophilia, leukemia, sickle-cell anemia)
Severe heart disease or heart valve failure
History of NAION or “crowded” optic disc
Retinitis pigmentosa

Medical Research Concerning Vigora

There have been plenty of studies on sildenafil, the active ingredient in Vigora, to assess how effective and safe it is in treating ED [1]. It’s also being studied as a treatment for pulmonary hypertension [2].

Individual companies’ research on such drugs, on the other hand, is lacking. This is because most companies just duplicate and follow the formula for an already available drug and have little need to do more research.

Are There Any Alternatives to Vigora?

There are plenty of medications that can treat ED. Most are prescription drugs that contain the same or similar ingredients as Vigora. It may be a good idea for you to look around a bit.

Pharmaceutical Alternatives

Vigora is the brand name for sildenafil, a generic medication made by many other companies. There are also other generic ED medications that work similar to Vigora. Your doctor can help you find one that suits you best.

Here are some of the alternatives for Vigora:

Sildenafil (Viagra, Cenforce, Kamagra, Fildena, P-Force, Vygex, & more)
Tadalafil (Cialis, Adcirca, Vidalista, Tadacip, Forzest, & more)
Avanafil (Avaforce, Stendra, Avana)
Mirodenafil (Mvix)
Udenafil (Zydena)
Vardenafil (Levitra, Staxyn, Vilitra, Savitra, & more)

Natural Alternatives

Instead of opting for a prescription right away, go the natural route — many herbs can help ED. If you’re unsure about your ED treatment, these may be a good place to start. You can switch to the pharmaceutical ones if they don’t work for you.

The following natural herbs and nutrients may aid in the treatment of ED:

Catuaba (Trichilia catigua or Erythroxylum catuaba) — Catuaba is used to relieve agitation and impaired memory, as well as promote sexual arousal and performance [3].
Zinc — Zinc deficiency might affect a man’s sexual competency by boosting testosterone levels and alleviate the symptoms of sexual dysfunctions [4].
Horny Goat Weed (Epimedium spp.) — This is a traditional Chinese medicinal herb that may aid in the treatment of erectile dysfunction and osteoporosis. Icarin, a chemical found in this plant, works as a PDE5 inhibitor [5].
L-Arginine — Oral L-arginine may improve sexual performance in males with erectile dysfunction by increasing cGMP, producing nitric oxide, and aiding in the formation of erections [6].
Korean Red Ginseng (Panax quinquefolium) – This can boost alertness and help with erectile dysfunction. The extracts have been shown to increase nitric oxide synthesis, stimulate artery dilatation in the penis, and elicit erection [7].

Where to Buy Vigora?

Vigora is only accessible with a prescription in most countries. You can go to your local drugstore or get it online if you have a prescription for it. The latter is the better alternative because it is more discreet and easier.

Before jumping into a prescription, test out a natural alternative to see if it helps. Adopting healthy choices can also make an improvment.

Otherwise, speak to your doctor about what treatment is best.

References Used

Hatzimouratidis, K. (2006). Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clinical interventions in aging, 1(4), 403.
Barnett, C. F., & Machado, R. F. (2006). Sildenafil in the treatment of pulmonary hypertension. Vascular health and risk management, 2(4), 411.
Lim, P. H. (2017). Asian herbals and aphrodisiacs are used for managing ED. Translational andrology and urology, 6(2), 167.
Dissanayake, D. M. A. B., Wijesinghe, P. S., Ratnasooriya, W. D., & Wimalasena, S. (2009). Effects of zinc supplementation on the sexual behavior of male rats. Journal of human reproductive sciences, 2(2), 57.
Shindel, A. W., Xin, Z. C., Lin, G., Fandel, T. M., Huang, Y. C., Banie, L., … & Lue, T. F. (2010). Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. The journal of sexual medicine, 7(4), 1518-1528.
Moody, J. A., Vernet, D., Laidlaw, S., Rajfer, J., & Gonzalez-Cadavid, N. F. (1997). Effects of long-term oral administration of L-arginine on the rat erectile response. The journal of urology, 158(3), 942-947.
De Andrade, E., De Mesquita, A. A., de Almeida Claro, J., De Andrade, P. M., Ortiz, V., Paranhos, M., … & Erdogrun, T. (2007). Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian journal of andrology, 9(2), 241-244.